Evaluating the association between all components of the metabolic syndrome and pre-eclampsia

Sindhu K. Srinivas, Mary D. Sammel, Jamie Bastek, Ella Ofori, Christina M. Andrela, Megan L. Wolfe, Muredach Reilly, Michal A. Elovitz

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Objective. Hypothesising that metabolic syndrome may be associated with or useful in the prediction of pre-eclampsia, we investigated the association between all components of metabolic syndrome and C-reactive protein (CRP) in women with and without pre-eclampsia. Methods. A casecontrol study was performed. Cases had gestational hypertension or pre-eclampsia and controls were term deliveries. Clinical data and maternal serum was collected. The presence of metabolic syndrome (3/5 variables present) and a metabolic score (continuous 0-5) were investigated. Significant associations were evaluated using t-tests, and Pearson chi-square tests of association. Multivariable logistic regression was used to control for confounders. Results. One-hundred and one cases and 267 controls were evaluated. We observed a higher odds of pre-eclampsia when metabolic syndrome was present (AOR=2.71[1.1-6.67], p=0.03). For every one-unit increase in metabolic score, there was a 39% increased odds of pre-eclampsia (AOR=1.39 [1.06-1.82], p 0.017. The odds of pre-eclampsia were nearly four times higher when hs- CRP was >8 (AOR 3.61 [2.14-6.12], p < 0.001). Conclusions. Metabolic syndrome and hs-CRP are associated with pre-eclampsia. Investigation is crucial to determine if these abnormal lipid and inflammatory pathways observed in women with pre-eclampsia are present pre-pregnancy or develop as a result of the disease process of pre-eclampsia. Further investigation is also warranted to determine whether these abnormalities persist post-pregnancy and if so, their contribution to long-term cardiovascular disease.

Original languageEnglish
Pages (from-to)501-509
Number of pages9
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number6
StatePublished - 2009
Externally publishedYes


  • Hypertensions
  • Lipids
  • Metabolic syndrome
  • Obesity
  • Pre-eclampsia


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