TY - JOUR
T1 - Evaluating routine diuretics after coronary surgery
T2 - A prospective randomized controlled trial
AU - Lim, Eric
AU - Ali, Ziad A.
AU - Attaran, Robert
AU - Cooper, Graham
N1 - Funding Information:
Grant support was provided by the Northern General Heart Research Fund. We would like to gratefully acknowledge the help of Mr Casula, Mr Locke, Mr Sharpe, and Mr Wilkinson for allowing us to randomize their patients.
PY - 2002
Y1 - 2002
N2 - Background. Routine diuretic administration after cardiopulmonary bypass is common despite the lack of evidence for its benefit. We performed a prospective study to evaluate if diuretics assist in weight loss or alter clinical outcome. Methods. Seventy-nine patients undergoing primary elective coronary bypass surgery were randomized to either diuretic (fusemide and amiloride) or placebo (lactose) postoperatively until preoperative weight was achieved or for 5 days in total. Proportions were compared with X2 or Fisher's exact test. Results. Forty patients were randomized to diuretics and 39 to placebo. By day 5, 97% of patients (37of 38) still in the diuretic arm, and 74% of patients (29 of 39) in the placebo arm, achieved preoperative weight (p = 0.02). There were no differences in clinical outcomes. Conclusions. Routine diuretics promote an earlier diuresis but no clinical benefits are apparent in low risk patients with normal renal function. Clinicians should reconsider routine diuretic prescription in this setting.
AB - Background. Routine diuretic administration after cardiopulmonary bypass is common despite the lack of evidence for its benefit. We performed a prospective study to evaluate if diuretics assist in weight loss or alter clinical outcome. Methods. Seventy-nine patients undergoing primary elective coronary bypass surgery were randomized to either diuretic (fusemide and amiloride) or placebo (lactose) postoperatively until preoperative weight was achieved or for 5 days in total. Proportions were compared with X2 or Fisher's exact test. Results. Forty patients were randomized to diuretics and 39 to placebo. By day 5, 97% of patients (37of 38) still in the diuretic arm, and 74% of patients (29 of 39) in the placebo arm, achieved preoperative weight (p = 0.02). There were no differences in clinical outcomes. Conclusions. Routine diuretics promote an earlier diuresis but no clinical benefits are apparent in low risk patients with normal renal function. Clinicians should reconsider routine diuretic prescription in this setting.
UR - http://www.scopus.com/inward/record.url?scp=0036149903&partnerID=8YFLogxK
U2 - 10.1016/S0003-4975(01)03311-2
DO - 10.1016/S0003-4975(01)03311-2
M3 - Article
C2 - 11834004
AN - SCOPUS:0036149903
SN - 0003-4975
VL - 73
SP - 153
EP - 155
JO - Annals of Thoracic Surgery
JF - Annals of Thoracic Surgery
IS - 1
ER -