Evaluating lleal Pouch Anal Anastomosis Function: Time to Expand Our ARM-amentarium

Yuying Luo, Natalia Schmidt, Marla C. Dubinsky, Barry Jaffin, Maia Kayal

Research output: Contribution to journalReview articlepeer-review


Background: Total proctocolectomy with ileal pouch anal anastomosis (IPAA) for medically refractory ulcerative colitis or dysplasia may be associated with structural and inflammatory complications. However, even in their absence, defecatory symptoms secondary to dyssynergic defecation or fecal incontinence may occur. Although anorectal manometry is well established as the diagnostic test of choice for defecatory symptoms, its utility in the assessment of patients with IPAA is less established. In this systematic review, we critically evaluate the existing evidence for anopouch manometry (APM). Methods: A total of 393 studies were identified, of which 6 studies met all inclusion criteria. Studies were not pooled given different modalities of testing with varying outcome measures. Results: Overall, less than 10% of symptomatic patients post-IPAA were referred to APM. The prevalence of dyssynergic defecation as defined by the Rome IV criteria in symptomatic patients with IPAA ranged from 47.0% to 100%. Fecal incontinence in patients with IPAA was characterized by decreased mean and maximal resting anal pressure on APM, as well as pouch hyposensitivity. The recto-anal inhibitory reflex was absent in most patients with and without incontinence. Conclusion: Manometry alone is an imperfect assessment of pouch function in patients with defecatory symptoms, and confirmatory testing may need to be performed with dynamic imaging.

Original languageEnglish
Pages (from-to)1819-1825
Number of pages7
JournalInflammatory Bowel Diseases
Issue number11
StatePublished - 1 Nov 2023


  • ileal pouch anal anastomosis
  • manometry


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