Eukaryotic DNA polymerases

Rinku Jain; Aneel K. Aggarwal; Olga Rechkoblit

doi:10.1016/j.sbi.2018.06.003

Eukaryotic DNA polymerases

Rinku Jain, Aneel K. Aggarwal, Olga Rechkoblit

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for cancer therapy.

Original language	English
Pages (from-to)	77-87
Number of pages	11
Journal	Current Opinion in Structural Biology
Volume	53
DOIs	https://doi.org/10.1016/j.sbi.2018.06.003
State	Published - Dec 2018

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title = "Eukaryotic DNA polymerases",

abstract = "The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for cancer therapy.",

author = "Rinku Jain and Aggarwal, {Aneel K.} and Olga Rechkoblit",

note = "Funding Information: The work in our laboratory is partially supported by NIH grants R01-CA200575 and R01GM126087 . Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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AU - Aggarwal, Aneel K.

AU - Rechkoblit, Olga

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N2 - The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for cancer therapy.

AB - The eukaryotic DNA replication machinery is conserved from yeast to humans and requires the actions of multiple DNA polymerases. In addition to replicative DNA polymerases for duplication of the leading and lagging DNA strands, another group of specialized polymerases is required for DNA repair and/or translesion DNA synthesis (TLS). We emphasize here recent findings that accelerate our understanding of the structure and mechanisms of these remarkable enzymes. We also highlight growing evidence on the role of DNA polymerases in the origin of certain cancers, and paradoxically as emerging targets for cancer therapy.

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DO - 10.1016/j.sbi.2018.06.003

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Eukaryotic DNA polymerases

Abstract

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