TY - JOUR
T1 - Ethnicity effect on the serum lipid profile in persons with spinal cord injury
AU - Bauman, William A.
AU - Adkins, Rodney H.
AU - Spungen, Ann M.
AU - Maloney, Patricia
AU - Gambino, Raymond
AU - Waters, Robert L.
N1 - Funding Information:
From the Spinal Cord Damage Research Center, Departments of Medicine and Rehabilitation Medicine. Mount Sinai Medical Center. New York. and Soinal Cord Injury Service, Veterans Affairs Medical Center, &xx, NY (drs. Bauman, Spungen); the Rehabilitation Research Training Center on Aging With Spinal Cord Injury (Drs. Bauman, Adkins, Waters) and Regional Spinal Cord System of Southern California (Drs. Adkins, Waters), Rancho Los Amieos Medical Center. Downey, CA; Quest‘ Diagnostics, Inc., Teterboro, NJ (Ms. Maloney, Dr. Gam: bino); and University of Southern California Medical Center, Los Angeles, CA (Dr. Waters). Submitted for publication March 19, 1997. Accepted in revised form June 6, 1997. Supported in part by grant Hl33B30029 from the National Institute on Disability and Rehabilitation Research (NIDRR). No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors or upon any organization with which the authors are associated. Reprint requests to Robert L. Waters, MD, Clinical Professor of Orthopedic Surgery, University of Southern California, Rancho Los Amigos Medical Center, 7601 East Imperial Highway HB-117, Downey, CA 90242. 0 1998 by the American Congress of Rehabilitation Medicine and the American Academy of Physical Medicine and Rehabilitation 0003.9993/98/7902-4440$3.00/O
PY - 1998/2
Y1 - 1998/2
N2 - Objective: The potential effect of ethnicity on the serum lipid profile and lipoprotein(a) [Lp(a)] was studied in a population with chronic spinal cord injury (SCI). Study Design: The distribution and correlates of high density lipoprotein (HDL) cholesterol and Lp(a) were studied in a population of 600 subjects with chronic SCI. Results: Mean ± SEM serum HDL cholesterol was significantly higher in the African American group than in the white and Latino groups (47 ± 1 vs 40 ± 1 and 38 ± 1mg/dL, p < .0001, respectively). The African American group had a lower serum total to HDL cholesterol ratio than white and Latino groups (4.46 ± .153 vs 5.18 ± .168 and 5.40 ± .140mg/dL, p < .01, respectively). Mean serum Lp(a) levels were significantly higher in the African American group than in Latino or white groups (29 ± 2 vs 18 ± 1 and 15 ± 1mg/dL, p < .0001, respectively). Age, duration of SCI, and level and completeness of lesion had no significant effect on serum Lp(a) level. Conclusions: In a population with chronic SCI, those in the African American group had the highest serum HDL cholesterol concentrations, the lowest serum total to HDL cholesterol ratios, and elevated levels of serum Lp(a) compared with the Latino and white groups. In a population of individuals with chronic SCI, ethnicity was shown to have a major effect on serum lipids and may be used to assist in the determination of cardiovascular risk.
AB - Objective: The potential effect of ethnicity on the serum lipid profile and lipoprotein(a) [Lp(a)] was studied in a population with chronic spinal cord injury (SCI). Study Design: The distribution and correlates of high density lipoprotein (HDL) cholesterol and Lp(a) were studied in a population of 600 subjects with chronic SCI. Results: Mean ± SEM serum HDL cholesterol was significantly higher in the African American group than in the white and Latino groups (47 ± 1 vs 40 ± 1 and 38 ± 1mg/dL, p < .0001, respectively). The African American group had a lower serum total to HDL cholesterol ratio than white and Latino groups (4.46 ± .153 vs 5.18 ± .168 and 5.40 ± .140mg/dL, p < .01, respectively). Mean serum Lp(a) levels were significantly higher in the African American group than in Latino or white groups (29 ± 2 vs 18 ± 1 and 15 ± 1mg/dL, p < .0001, respectively). Age, duration of SCI, and level and completeness of lesion had no significant effect on serum Lp(a) level. Conclusions: In a population with chronic SCI, those in the African American group had the highest serum HDL cholesterol concentrations, the lowest serum total to HDL cholesterol ratios, and elevated levels of serum Lp(a) compared with the Latino and white groups. In a population of individuals with chronic SCI, ethnicity was shown to have a major effect on serum lipids and may be used to assist in the determination of cardiovascular risk.
UR - http://www.scopus.com/inward/record.url?scp=0031905731&partnerID=8YFLogxK
U2 - 10.1016/S0003-9993(98)90296-9
DO - 10.1016/S0003-9993(98)90296-9
M3 - Article
C2 - 9474000
AN - SCOPUS:0031905731
SN - 0003-9993
VL - 79
SP - 176
EP - 180
JO - Archives of Physical Medicine and Rehabilitation
JF - Archives of Physical Medicine and Rehabilitation
IS - 2
ER -