Ethanol suppresses hippocampal cell firing through a calcium and cyclic AMP-sensitive mechanism

Deborah M. Benson, Robert D. Blitzer, Emmanuel M. Landau

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

The effects of ethanol were studied intracellularly in hippocampal pyramidal cells in vitro. Ethanol, 50-100 mM, produced a marked suppression of neuronal firing. This effect was blocked by treating the cell with cyclic 3′, 5′-adenosine monophosphate (cAMP) or cadmium ions. Ethanol had no effect on the after-hyperpolarizing current. It is concluded that the ethanol-induced reduction of firing rate is due to a calcium-dependent process, and modulated by cAMP.

Original languageEnglish
Pages (from-to)591-594
Number of pages4
JournalEuropean Journal of Pharmacology
Volume164
Issue number3
DOIs
StatePublished - 30 May 1989

Keywords

  • (Neuronal firing)
  • After-hyperpolarization
  • Ca
  • Ethanol
  • Hippocampus
  • cAMP

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