TY - JOUR
T1 - Ethanol intake and the risk of pancreatic cancer in the European prospective investigation into cancer and nutrition (EPIC)
AU - Rohrmann, Sabine
AU - Linseisen, Jakob
AU - Vrieling, Alina
AU - Boffetta, Paolo
AU - Stolzenberg-Solomon, Rachael Z.
AU - Lowenfels, Albert B.
AU - Jensen, Majken K.
AU - Overvad, Kim
AU - Olsen, Anja
AU - Tjonneland, Anne
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - Fagherazzi, G.
AU - Misirli, Gesthimani
AU - Lagiou, Pagona
AU - Trichopoulou, Antonia
AU - Kaaks, Rudolf
AU - Bergmann, Manuela M.
AU - Boeing, Heiner
AU - Bingham, Sheila
AU - Khaw, Kay Tee
AU - Allen, Naomi
AU - Roddam, Andrew
AU - Palli, Domenico
AU - Pala, Valeria
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Peeters, Petra H.M.
AU - Hjartåker, Anette
AU - Lund, Eiliv
AU - Cornejo, Ma Luisa Redondo
AU - Agudo, Antonio
AU - Arriola, Larraitz
AU - Sánchez, Maria José
AU - Tormo, María José
AU - Barricarte Gurrea, Aurelio
AU - Lindkvist, Björn
AU - Manjer, Jonas
AU - Johansson, Ingegerd
AU - Ye, Weimin
AU - Slimani, Nadia
AU - Duell, Eric J.
AU - Jenab, Mazda
AU - Michaud, Dominique S.
AU - Mouw, Traci
AU - Riboli, Elio
AU - Bueno-De-Mesquita, H. Bas
N1 - Funding Information:
Acknowledgments European Commission: Public Health and Consumer Protection Directorate 1993–2004; Research Directorate-General 2005-; Deutsche Krebshilfe, Deutsches Krebsforschungs-zentrum, German Federal Ministry of Education and Research; Danish Cancer Society; Health Research Fund (FIS) of the Spanish Ministry of Health, Spanish Regional Governments of Andalucia, Asturias, Basque Country, Murcia and Navarra; the ISCIII Network RCESP (C03/09), Spain; Cancer Research UK; Medical Research Council, United Kingdom; Stroke Association, United Kingdom; British Heart Foundation; Department of Health, United Kingdom; Food Standards Agency, United Kingdom; Wellcome Trust, United Kingdom; Greek Ministry of Health; Greek Ministry of Education; Italian Association for Research on Cancer (AIRC); Italian National Research Council, Fondazione-Istituto Banco Napoli, Italy; Com-pagnia di San Paolo; Dutch Ministry of Public Health, Welfare and Sports; World Cancer Research Fund; Swedish Cancer Society; Swedish Scientific Council; Regional Government of Skåne, Sweden; Norwegian Cancer Society; Research Council of Norway; French League against Cancer (LNCC); National Institute for Health and Medical Research (INSERM), France; Mutuelle Générale de l’Education Nationale (MGEN), France; 3 M Co, France; Gustave Roussy Institute (IGR), France; and General Councils of France
PY - 2009/7
Y1 - 2009/7
N2 - Objective: To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Results: Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. Conclusion: These results suggest no association of alcohol consumption with the risk of pancreatic cancer.
AB - Objective: To examine the association of baseline and lifetime ethanol intake with cancer of the pancreas in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: Included in this analysis were 478,400 subjects, of whom detailed information on the intake of alcoholic beverages at baseline and over lifetime was collected between 1992 and 2000. During a median follow-up time of 8.9 years, 555 non-endocrine pancreatic cancer cases were observed. Multivariate Cox proportional hazard models were used to examine the association of ethanol intake at recruitment and average lifetime ethanol intake and pancreatic cancer adjusting for smoking, height, weight, and history of diabetes. Results: Overall, neither ethanol intake at recruitment (relative risk (RR) = 0.94, 95% confidence interval (CI) 0.69-1.27 comparing 30+ g/d vs. 0.1-4.9 g/d) nor average lifetime ethanol intake (RR = 0.95, 95% CI 0.65-1.39) was associated with pancreatic cancer risk. High lifetime ethanol intake from spirits/liquor at recruitment tended to be associated with a higher risk (RR = 1.40, 95% CI 0.93-2.10 comparing 10+ g/d vs. 0.1-4.9 g/d), but no associations were observed for wine and beer consumption. Conclusion: These results suggest no association of alcohol consumption with the risk of pancreatic cancer.
KW - EPIC
KW - Epidemiology
KW - Ethanol
KW - Pancreatic cancer
UR - http://www.scopus.com/inward/record.url?scp=67349214047&partnerID=8YFLogxK
U2 - 10.1007/s10552-008-9293-8
DO - 10.1007/s10552-008-9293-8
M3 - Article
C2 - 19145468
AN - SCOPUS:67349214047
SN - 0957-5243
VL - 20
SP - 785
EP - 794
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 5
ER -