TY - JOUR
T1 - Ethanol enhancement of the motor-stimulating effect of nicotine in the rat
AU - Lapin, E. P.
AU - Maker, H. S.
AU - Bhardwaj, A.
PY - 1995
Y1 - 1995
N2 - Although ethanol stimulates locomotion in mice, it has been difficult to demonstrate such an action in rats. In contrast, nicotine has been shown to enhance locomotion, including ipsiversive rotation in nigral-lesioned rats. We found no significant effect of ethanol alone on rat rotation at doses of 0.125, 0.50, 1.0, and 2.0 g/kg, IP, during a 30-min observation period. However, there was a dose-dependent effect of ethanol enhancing the rotation induced by nicotine (0.4 mg/kg, SC) given 30 min after the ethanol. The interaction of ethanol and nicotine on locomotion most likely involves the release of dopamine and may be related to the motor abnormalities sometimes seen clinically.
AB - Although ethanol stimulates locomotion in mice, it has been difficult to demonstrate such an action in rats. In contrast, nicotine has been shown to enhance locomotion, including ipsiversive rotation in nigral-lesioned rats. We found no significant effect of ethanol alone on rat rotation at doses of 0.125, 0.50, 1.0, and 2.0 g/kg, IP, during a 30-min observation period. However, there was a dose-dependent effect of ethanol enhancing the rotation induced by nicotine (0.4 mg/kg, SC) given 30 min after the ethanol. The interaction of ethanol and nicotine on locomotion most likely involves the release of dopamine and may be related to the motor abnormalities sometimes seen clinically.
KW - Ethanol enhancement of nicotine
KW - Lesions of the substantia nigra
KW - Nicotine-ethanol interaction
KW - Nicotine-induced rotation
UR - http://www.scopus.com/inward/record.url?scp=0029055632&partnerID=8YFLogxK
U2 - 10.1016/0741-8329(94)00097-W
DO - 10.1016/0741-8329(94)00097-W
M3 - Article
C2 - 7639954
AN - SCOPUS:0029055632
SN - 0741-8329
VL - 12
SP - 217
EP - 220
JO - Alcohol
JF - Alcohol
IS - 3
ER -