Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig

P. Nicoletti; M. Trevisani; M. Manconi; R. Gatti; G. De Siena; G. Zagli; S. Benemei; J. A. Capone; P. Geppetti; L. A. Pini

doi:10.1111/j.1468-2982.2007.01448.x

Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig

P. Nicoletti, M. Trevisani, M. Manconi, R. Gatti, G. De Siena, G. Zagli, S. Benemei, J. A. Capone, P. Geppetti, L. A. Pini

Research output: Contribution to journal › Article › peer-review

98 Scopus citations

Abstract

Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes neurogenic inflammation, including calcitonin gene-related peptide (CGRP)-mediated coronary dilation. Alcoholic beverages trigger migraine attacks and activation of trigeminal neurons plays a role in migraine. We have investigated in guinea pigs whether ethanol by TRPV1 stimulation causes neurogenic inflammation in the trigeminovascular system. Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by Ca²⁺ removal, capsaicin pretreatment and the TRPV1 antagonist, capsazepine. Intragastric ethanol increased plasma extravasation in dura mater, an effect abolished by capsazepine and the NK1 receptor antagonist, SR140333, and caused vasodilation around the middle meningeal artery, an effect abolished by capsazepine and the CGRP receptor antagonist, BIBN4096BS. Vasodilation of meningeal vessels by TRPV1 activation and CGRP release may be relevant to the mechanism by which alcohol ingestion triggers migraine attacks.

Original language	English
Pages (from-to)	9-17
Number of pages	9
Journal	Cephalalgia
Volume	28
Issue number	1
DOIs	https://doi.org/10.1111/j.1468-2982.2007.01448.x
State	Published - Jan 2008
Externally published	Yes

Keywords

BIBN4096BS
CGRP
Dural neurogenic vasodilation
Ethanol
TRPV1

Access to Document

10.1111/j.1468-2982.2007.01448.x

Cite this

@article{e41d8444431f4933a3a3cb66f7f50cf8,

title = "Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig",

abstract = "Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes neurogenic inflammation, including calcitonin gene-related peptide (CGRP)-mediated coronary dilation. Alcoholic beverages trigger migraine attacks and activation of trigeminal neurons plays a role in migraine. We have investigated in guinea pigs whether ethanol by TRPV1 stimulation causes neurogenic inflammation in the trigeminovascular system. Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by Ca2+ removal, capsaicin pretreatment and the TRPV1 antagonist, capsazepine. Intragastric ethanol increased plasma extravasation in dura mater, an effect abolished by capsazepine and the NK1 receptor antagonist, SR140333, and caused vasodilation around the middle meningeal artery, an effect abolished by capsazepine and the CGRP receptor antagonist, BIBN4096BS. Vasodilation of meningeal vessels by TRPV1 activation and CGRP release may be relevant to the mechanism by which alcohol ingestion triggers migraine attacks.",

keywords = "BIBN4096BS, CGRP, Dural neurogenic vasodilation, Ethanol, TRPV1",

author = "P. Nicoletti and M. Trevisani and M. Manconi and R. Gatti and {De Siena}, G. and G. Zagli and S. Benemei and Capone, {J. A.} and P. Geppetti and Pini, {L. A.}",

year = "2008",

month = jan,

doi = "10.1111/j.1468-2982.2007.01448.x",

language = "English",

volume = "28",

pages = "9--17",

journal = "Cephalalgia",

issn = "0333-1024",

publisher = "SAGE Publications Ltd",

number = "1",

}

TY - JOUR

T1 - Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig

AU - Nicoletti, P.

AU - Trevisani, M.

AU - Manconi, M.

AU - Gatti, R.

AU - De Siena, G.

AU - Zagli, G.

AU - Benemei, S.

AU - Capone, J. A.

AU - Geppetti, P.

AU - Pini, L. A.

PY - 2008/1

Y1 - 2008/1

N2 - Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes neurogenic inflammation, including calcitonin gene-related peptide (CGRP)-mediated coronary dilation. Alcoholic beverages trigger migraine attacks and activation of trigeminal neurons plays a role in migraine. We have investigated in guinea pigs whether ethanol by TRPV1 stimulation causes neurogenic inflammation in the trigeminovascular system. Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by Ca2+ removal, capsaicin pretreatment and the TRPV1 antagonist, capsazepine. Intragastric ethanol increased plasma extravasation in dura mater, an effect abolished by capsazepine and the NK1 receptor antagonist, SR140333, and caused vasodilation around the middle meningeal artery, an effect abolished by capsazepine and the CGRP receptor antagonist, BIBN4096BS. Vasodilation of meningeal vessels by TRPV1 activation and CGRP release may be relevant to the mechanism by which alcohol ingestion triggers migraine attacks.

AB - Ethanol stimulating transient receptor potential vanilloid 1 (TRPV1) on primary sensory neurons promotes neurogenic inflammation, including calcitonin gene-related peptide (CGRP)-mediated coronary dilation. Alcoholic beverages trigger migraine attacks and activation of trigeminal neurons plays a role in migraine. We have investigated in guinea pigs whether ethanol by TRPV1 stimulation causes neurogenic inflammation in the trigeminovascular system. Ethanol-evoked release of neuropeptides from slices of dura mater was abolished by Ca2+ removal, capsaicin pretreatment and the TRPV1 antagonist, capsazepine. Intragastric ethanol increased plasma extravasation in dura mater, an effect abolished by capsazepine and the NK1 receptor antagonist, SR140333, and caused vasodilation around the middle meningeal artery, an effect abolished by capsazepine and the CGRP receptor antagonist, BIBN4096BS. Vasodilation of meningeal vessels by TRPV1 activation and CGRP release may be relevant to the mechanism by which alcohol ingestion triggers migraine attacks.

KW - BIBN4096BS

KW - CGRP

KW - Dural neurogenic vasodilation

KW - Ethanol

KW - TRPV1

UR - http://www.scopus.com/inward/record.url?scp=36749048746&partnerID=8YFLogxK

U2 - 10.1111/j.1468-2982.2007.01448.x

DO - 10.1111/j.1468-2982.2007.01448.x

M3 - Article

C2 - 17888011

AN - SCOPUS:36749048746

SN - 0333-1024

VL - 28

SP - 9

EP - 17

JO - Cephalalgia

JF - Cephalalgia

IS - 1

ER -

Ethanol causes neurogenic vasodilation by TRPV1 activation and CGRP release in the trigeminovascular system of the guinea pig

Abstract

Keywords

Access to Document

Fingerprint

Cite this