Ethanol administration in vivo alters calcium ions control in rat striatum

Laura Lucchi, Stefano Govoni, Fiorenzo Battaini, Giulio Pasinetti, Marco Trabucchi

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36 Scopus citations

Abstract

The present paper investigates the effect of chronic ethanol treatment administered through drinking water on [3H]nitrendipine binding and 45Ca3uptake in rat striatum. The calcium-independent [3H]nitrendipine binding was slightly increased in treated rats, while the calcium stimulation of the binding was reduced to one fifth of the controls. In striatal slices prepared from a similar group of ethanol-treated rats the K+-stimulated 45Ca uptake was greatly reduced. These results are the first evidence of calcium-antagonist binding-site 'plasticity' following an in vivo pharmacological manipulation correlated with a change in calcium ion transport. In addition, the effect of ethanol on calcium-entry regulation may be a mechanism important for the understanding of its neurotoxic action.

Original languageEnglish
Pages (from-to)376-379
Number of pages4
JournalBrain Research
Volume332
Issue number2
DOIs
StatePublished - 22 Apr 1985
Externally publishedYes

Keywords

  • [H]nitrendipine
  • calcium ion
  • ethanol
  • striatum

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