Abstract
The present paper investigates the effect of chronic ethanol treatment administered through drinking water on [3H]nitrendipine binding and 45Ca3uptake in rat striatum. The calcium-independent [3H]nitrendipine binding was slightly increased in treated rats, while the calcium stimulation of the binding was reduced to one fifth of the controls. In striatal slices prepared from a similar group of ethanol-treated rats the K+-stimulated 45Ca uptake was greatly reduced. These results are the first evidence of calcium-antagonist binding-site 'plasticity' following an in vivo pharmacological manipulation correlated with a change in calcium ion transport. In addition, the effect of ethanol on calcium-entry regulation may be a mechanism important for the understanding of its neurotoxic action.
Original language | English |
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Pages (from-to) | 376-379 |
Number of pages | 4 |
Journal | Brain Research |
Volume | 332 |
Issue number | 2 |
DOIs | |
State | Published - 22 Apr 1985 |
Externally published | Yes |
Keywords
- [H]nitrendipine
- calcium ion
- ethanol
- striatum