Estrogen reduces neuronal generation of Alzheimer β-amyloid peptides

Huaxi Xu, Gunnar K. Gouras, Jeffrey P. Greenfield, Bruno Vincent, Jan Naslund, Louis Mazzarelli, Gabriel Fried, Jasmina N. Jovanovic, Mary Seeger, Norman R. Relkin, Fang Liao, Frédéric Checler, Joseph D. Buxbaum, Brian T. Chait, Gopal Thinakaran, Sangram S. Sisodia, Rong Wang, Paul Greengard, Sam Gandy

Research output: Contribution to journalArticlepeer-review

526 Scopus citations

Abstract

Alzheimer's disease (AD) is characterized by the accumulation of cerebral plaques composed of 40- and 42-amino acid ̄-amyloid (Aβ) peptides, and autosomal dominant forms of AD appear to cause disease by promoting brain Aβ accumulation. Recent studies indicate that postmenopausal estrogen replacement therapy may prevent or delay the onset of AD. Here we present evidence that physiological levels of 17β-estradiol reduce the generation of Aβ by neuroblastoma cells and by primary cultures of rat, mouse and human embryonic cerebrocortical neurons. These results suggest a mechanism by which estrogen replacement therapy can delay or prevent AD.

Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalNature Medicine
Volume4
Issue number4
DOIs
StatePublished - Apr 1998
Externally publishedYes

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