TY - JOUR
T1 - Estrogen receptor beta rs1271572 polymorphism and invasive ovarian carcinoma risk
T2 - Pooled analysis within the ovarian cancer association consortium
AU - Lurie, Galina
AU - Wilkens, Lynne R.
AU - Thompson, Pamela J.
AU - Shvetsov, Yurii B.
AU - Matsuno, Rayna K.
AU - Carney, Michael E.
AU - Palmieri, Rachel T.
AU - Wu, Anna H.
AU - Pike, Malcolm C.
AU - Pearce, Celeste L.
AU - Menon, Usha
AU - Gentry-Maharaj, Aleksandra
AU - Gayther, Simon A.
AU - Ramus, Susan J.
AU - Whittemore, Alice S.
AU - McGuire, Valerie
AU - Sieh, Weiva
AU - Pharoah, Paul D.P.
AU - Song, Honglin
AU - Gronwald, Jacek
AU - Jakubowska, Anna
AU - Cybulski, Cezary
AU - Lubinski, Jan
AU - Schildkraut, Joellen M.
AU - Berchuck, Andrew
AU - Kjær, Susanne
AU - Høgdall, Estrid
AU - Fasching, Peter A.
AU - Beckmann, Matthias W.
AU - Ekici, Arif B.
AU - Hein, Alexander
AU - Chenevix-Trench, Georgia
AU - Webb, Penelope M.
AU - Beesley, Jonathan
AU - The Australian Ovarian Cancer Study, Australian Ovarian Cancer Study
AU - Goodman, Marc T.
AU - The Ovarian Cancer Association Consortium, Ovarian Cancer Association Consortium
PY - 2011
Y1 - 2011
N2 - The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
AB - The association of ovarian carcinoma risk with the polymorphism rs1271572 in the estrogen receptor beta (ESR2) gene was examined in 4946 women with primary invasive ovarian carcinoma and 6582 controls in a pooled analysis of ten case-control studies within the Ovarian Cancer Association Consortium (OCAC). All participants were non-Hispanic white women. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using unconditional logistic regression adjusted for site and age. Women with the TT genotype were at increased risk of ovarian carcinoma compared to carriers of the G allele (OR = 1.10; 95%; CI: 1.01-1.21; p = 0.04); the OR was 1.09 (CI: 0.99-1.20; p = 0.07) after excluding data from the center (Hawaii) that nominated this SNP for OCAC genotyping A stronger association of rs1271572 TT versus GT/GG with risk was observed among women aged ≤50 years versus older women (OR = 1.35; CI: 1.12-1.62; p = 0.002; p for interaction = 0.02) that remained statistically significant after excluding Hawaii data (OR = 1.34; CI: 1.11-1.61; p = 0.009). No heterogeneity of the association was observed by study, menopausal status, gravidity, parity, use of contraceptive or menopausal hormones, tumor histological type, or stage at diagnosis. This pooled analysis suggests that rs1271572 might influence the risk of ovarian cancer, in particular among younger women.
UR - http://www.scopus.com/inward/record.url?scp=79958128164&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0020703
DO - 10.1371/journal.pone.0020703
M3 - Article
C2 - 21673961
AN - SCOPUS:79958128164
SN - 1932-6203
VL - 6
JO - PLoS ONE
JF - PLoS ONE
IS - 6
M1 - e20703
ER -