@article{beafdc093ee04abbb80804389815373a,
title = "Estrogen receptor α drives pro-resilient transcription in mouse models of depression",
abstract = "Most people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (NAc), a key brain reward region implicated in depression. In accordance with these findings, nuclear ERα protein levels are altered by stress in male and female mice. Further, overexpression of ERα in the NAc promotes stress resilience in both sexes. Subsequent RNA-sequencing reveals that ERα overexpression in NAc reproduces the transcriptional signature of resilience in male, but not female, mice. These results indicate that NAc ERα is an important regulator of pro-resilient transcriptional changes, but with sex-specific downstream targets.",
author = "Lorsch, {Zachary S.} and Loh, {Yong Hwee Eddie} and Immanuel Purushothaman and Walker, {Deena M.} and Parise, {Eric M.} and Marine Salery and Cahill, {Michael E.} and Hodes, {Georgia E.} and Pfau, {Madeline L.} and Hope Kronman and Hamilton, {Peter J.} and Orna Issler and Benoit Labont{\'e} and Symonds, {Ann E.} and Matthew Zucker and Zhang, {Tie Yuan} and Meaney, {Michael J.} and Russo, {Scott J.} and Li Shen and Bagot, {Rosemary C.} and Nestler, {Eric J.}",
note = "Funding Information: This work was supported by National Institutes of Health grants F30MH110073 (Z.S.L.), T32GM007280 (Z.S.L.), T32MH096678 (Z.S.L.), and P50MH096890 (E.J.N.), NARSAD Young Investigator Award 22713 (R.C.B.) and the Hope for Depression Research Foundation. We thank Catherine J. Pe{\~n}a (Icahn School of Medicine at Mount Sinai) and Erin S. Calipari (Vanderbilt University) for their helpful comments on the manuscript. Publisher Copyright: {\textcopyright} 2018 The Author(s).",
year = "2018",
month = dec,
day = "1",
doi = "10.1038/s41467-018-03567-4",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}