72 Scopus citations


Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.

Original languageEnglish
Pages (from-to)473-484
Number of pages12
JournalEndocrinology and Metabolism Clinics of North America
Issue number3
StatePublished - Sep 2011


  • Breast cancer
  • Estrogen receptor
  • Knockout mice
  • Mammary gland development
  • Transcription factor


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