Estrogen Carcinogenesis in Breast Cancer

Doris Germain

doi:10.1016/j.ecl.2011.05.009

Estrogen Carcinogenesis in Breast Cancer

Doris Germain

Research output: Contribution to journal › Review article › peer-review

69 Scopus citations

Abstract

Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.

Original language	English
Pages (from-to)	473-484
Number of pages	12
Journal	Endocrinology and Metabolism Clinics of North America
Volume	40
Issue number	3
DOIs	https://doi.org/10.1016/j.ecl.2011.05.009
State	Published - Sep 2011

Keywords

Breast cancer
Estrogen receptor
Knockout mice
Mammary gland development
Transcription factor

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10.1016/j.ecl.2011.05.009

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title = "Estrogen Carcinogenesis in Breast Cancer",

abstract = "Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.",

keywords = "Breast cancer, Estrogen receptor, Knockout mice, Mammary gland development, Transcription factor",

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AB - Many studies have reported a correlation between elevated estrogen blood levels and breast cancer and this observation has raised controversy concerning the long-term use of hormonal replacement therapy. This review will not address further this controversial topic; but rather, this review focuses on the role of estrogen signaling in first, the normal development of the breast and second, how alterations of this signaling pathway contribute to breast cancer.

KW - Breast cancer

KW - Estrogen receptor

KW - Knockout mice

KW - Mammary gland development

KW - Transcription factor

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JF - Endocrinology and Metabolism Clinics of North America

IS - 3

ER -

Estrogen Carcinogenesis in Breast Cancer

Abstract

Keywords

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