TY - JOUR
T1 - Estradiol overcomes adiponectin-resistance in diabetic mice by regulating skeletal muscle adiponectin receptor 1 expression
AU - Chattopadhyay, Sourav
AU - Joharapurkar, Amit
AU - Das, Nabanita
AU - Khatoon, Shamima
AU - Kushwaha, Sapana
AU - Gurjar, Anagha Ashok
AU - Singh, Abhishek Kumar
AU - Shree, Sonal
AU - Ahmed, Md Zohaib
AU - China, Shyamsundar Pal
AU - Pal, Subhashis
AU - Kumar, Harish
AU - Ramachandran, Ravishankar
AU - Patel, Vishal
AU - Trivedi, Arun Kumar
AU - Lahiri, Amit
AU - Jain, Mukul Rameshchandra
AU - Chattopadhyay, Naibedya
AU - Sanyal, Sabyasachi
N1 - Publisher Copyright:
© 2021
PY - 2022/1/15
Y1 - 2022/1/15
N2 - Adiponectin and insulin resistance creates a vicious cycle that exacerbates type 2 diabetes. Earlier, we observed that female leptin receptor-deficient BLKS mice (BKS-db/db) were more sensitive to an adiponectin mimetic GTDF than males, which led us to explore if E2 plays a crucial role in modulation of adiponectin-sensitivity. Male but not female BKS-db/db mice were resistant to metabolic effects of globular adiponectin treatment. Male BKS-db/db displayed reduced skeletal muscle AdipoR1 protein expression, which was consequent to elevated polypyrimidine tract binding protein 1 (PTB) and miR-221. E2 treatment in male BKS-db/db, and ovariectomized BALB/c mice rescued AdipoR1 protein expression via downregulation of PTB and miR-221, and also directly increased AdipoR1 mRNA by its classical nuclear receptors. Estrogen receptor regulation via dietary or pharmacological interventions may improve adiponectin resistance and consequently ameliorate insulin resistance in type 2 diabetes.
AB - Adiponectin and insulin resistance creates a vicious cycle that exacerbates type 2 diabetes. Earlier, we observed that female leptin receptor-deficient BLKS mice (BKS-db/db) were more sensitive to an adiponectin mimetic GTDF than males, which led us to explore if E2 plays a crucial role in modulation of adiponectin-sensitivity. Male but not female BKS-db/db mice were resistant to metabolic effects of globular adiponectin treatment. Male BKS-db/db displayed reduced skeletal muscle AdipoR1 protein expression, which was consequent to elevated polypyrimidine tract binding protein 1 (PTB) and miR-221. E2 treatment in male BKS-db/db, and ovariectomized BALB/c mice rescued AdipoR1 protein expression via downregulation of PTB and miR-221, and also directly increased AdipoR1 mRNA by its classical nuclear receptors. Estrogen receptor regulation via dietary or pharmacological interventions may improve adiponectin resistance and consequently ameliorate insulin resistance in type 2 diabetes.
KW - AdipoR
KW - Adiponectin
KW - Estradiol
KW - Estrogen receptor
KW - PTBP1
KW - miR-221
UR - http://www.scopus.com/inward/record.url?scp=85120352475&partnerID=8YFLogxK
U2 - 10.1016/j.mce.2021.111525
DO - 10.1016/j.mce.2021.111525
M3 - Article
C2 - 34856343
AN - SCOPUS:85120352475
SN - 0303-7207
VL - 540
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
M1 - 111525
ER -