Estradiol-mediated tumor neo-vascularization

Shilpi Rajoria, Robert Suriano, Yushan L. Wilson, Andrea L. George, Jan Geliebter, Stimson P. Schantz, Raj K. Tiwari

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Neo-vascularization is essential for tumor growth and metastasis and is presumably initiated by bone marrow-derived endothelial progenitor cells (BM-EPCs). These cells predominantly reside in the bone marrow and are recruited at sites of inflammation, tissue damage and tumors. The tissue-specific factors responsible for recruitment of BM-EPCs and neo-vascularization are the subject of intense investigation. Using bone marrow cells from Tek/green fluorescent protein (GFP) transgenic mice, we analyzed the effect of estrogen on the mobilization of BM-EPCs to orthotopically implanted cancer cells in estrogen- and non-estrogen-supplemented ovariectomized mice. The donor marrow cells were unique as they were fluorescently tagged, allowing for the tracking of their migration to the tumor tissues. Results showed that GFP + BM-EPCs were incorporated within the tumor vasculature in comparison to the sham injections. Notably, estrogen supplementation enhanced the mobilization of BM-EPCs to the tumor site. This elevation shows that estrogen may affect tumor neo-vascularization by inducing the mobilization of BM-EPCs. Understanding and characterizing the mechanism involved in the estrogen-induced mobilization of BM-EPCs may serve as a 'Trojan horse' in the delivery of bio-molecules that may disrupt tumor vasculogenesis and induce the targeted killing of tumor cells.

Original languageEnglish
Pages (from-to)453-457
Number of pages5
JournalOncology Letters
Issue number3
StatePublished - May 2011
Externally publishedYes


  • Bone marrow-endothelial progenitor cells
  • Estrogen
  • Neo-vascularization


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