Abstract
A continuous human colon carcinoma cell line (HuCCL-14) was established whose cells possess an epithelial-like morphology and are capable of growing in soft agar and on monolayers of normal cells. HuCCL-14 cells yielded high levels of carcinoembryonic antigen, and the analysis of their chromosomal constitution revealed a mode of 70 chromosomes per cell. HuCCL-14 cells produce malignant tumors when injected into nude mice. Preliminary virologic studies indicate the release of RNA particles having a density of K15-1.19 g/ml.
| Original language | English |
|---|---|
| Pages (from-to) | 220-230 |
| Number of pages | 11 |
| Journal | Pathobiology |
| Volume | 46 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1978 |
| Externally published | Yes |
Keywords
- CEA
- Cell line
- Colon carcinoma
- Karyotype
- Malignancy
- RNA particles
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