Essential roles for the Abl and Arg tyrosine kinases in neurulation

Anthony J. Koleske, Ann M. Gifford, Martin L. Scott, Michelle Nee, Roderick T. Bronson, Klaus A. Miczek, David Baltimore

Research output: Contribution to journalArticlepeer-review

334 Scopus citations

Abstract

The Abl and Arg tyrosine kinases play fundamental roles in the development and function of the central nervous system. Arg is most abundant in adult mouse brain, especially in synapse-rich regions. arg(-/-) mice develop normally but exhibit multiple behavioral abnormalities, suggesting that arg(-/-) brains suffer from defects in neuronal function. Embryos deficient in both Abl and Arg suffer from defects in neurulation and die before 11 days postcoitum (dpc). Although they divide normally, abl(-/- )arg(-/-) neuroepithelial cells display gross alterations in their actin cytoskeleton. We find that Abl and Arg colocalize with each other and with actin microfilaments at the apical surface of the developing neuroepithelium. Thus, Abl and Arg play essential roles in neurulation and can regulate the structure of the actin cytoskeleton.

Original languageEnglish
Pages (from-to)1259-1272
Number of pages14
JournalNeuron
Volume21
Issue number6
DOIs
StatePublished - Dec 1998
Externally publishedYes

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