Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Swarna Mehrotra; Bhumika Sharma; Sonali Joshi; Barbara Kroczynska; Beata Majchrzak; Brady L. Stein; Brandon McMahon; Jessica K. Altman; Jonathan D. Licht; Darren P. Baker; Elizabeth A. Eklund; Amittha Wickrema; Amit Verma; Eleanor N. Fish; Leonidas C. Platanias

doi:10.1074/jbc.M113.476192

Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Swarna Mehrotra, Bhumika Sharma, Sonali Joshi, Barbara Kroczynska, Beata Majchrzak, Brady L. Stein, Brandon McMahon, Jessica K. Altman, Jonathan D. Licht, Darren P. Baker, Elizabeth A. Eklund, Amittha Wickrema, Amit Verma, Eleanor N. Fish, Leonidas C. Platanias

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

Original language	English
Pages (from-to)	23814-23822
Number of pages	9
Journal	Journal of Biological Chemistry
Volume	288
Issue number	33
DOIs	https://doi.org/10.1074/jbc.M113.476192
State	Published - 16 Aug 2013
Externally published	Yes

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Mehrotra, S., Sharma, B., Joshi, S., Kroczynska, B., Majchrzak, B., Stein, B. L., McMahon, B., Altman, J. K., Licht, J. D., Baker, D. P., Eklund, E. A., Wickrema, A., Verma, A., Fish, E. N., & Platanias, L. C. (2013). Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors. Journal of Biological Chemistry, 288(33), 23814-23822. https://doi.org/10.1074/jbc.M113.476192

@article{d7b0a47571d24251a15a07977f4145b1,

title = "Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors",

abstract = "Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.",

author = "Swarna Mehrotra and Bhumika Sharma and Sonali Joshi and Barbara Kroczynska and Beata Majchrzak and Stein, \{Brady L.\} and Brandon McMahon and Altman, \{Jessica K.\} and Licht, \{Jonathan D.\} and Baker, \{Darren P.\} and Eklund, \{Elizabeth A.\} and Amittha Wickrema and Amit Verma and Fish, \{Eleanor N.\} and Platanias, \{Leonidas C.\}",

year = "2013",

month = aug,

day = "16",

doi = "10.1074/jbc.M113.476192",

language = "English",

volume = "288",

pages = "23814--23822",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "33",

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Mehrotra, S, Sharma, B, Joshi, S, Kroczynska, B, Majchrzak, B, Stein, BL, McMahon, B, Altman, JK, Licht, JD, Baker, DP, Eklund, EA, Wickrema, A, Verma, A, Fish, EN & Platanias, LC 2013, 'Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors', Journal of Biological Chemistry, vol. 288, no. 33, pp. 23814-23822. https://doi.org/10.1074/jbc.M113.476192

TY - JOUR

T1 - Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

AU - Mehrotra, Swarna

AU - Sharma, Bhumika

AU - Joshi, Sonali

AU - Kroczynska, Barbara

AU - Majchrzak, Beata

AU - Stein, Brady L.

AU - McMahon, Brandon

AU - Altman, Jessica K.

AU - Licht, Jonathan D.

AU - Baker, Darren P.

AU - Eklund, Elizabeth A.

AU - Wickrema, Amittha

AU - Verma, Amit

AU - Fish, Eleanor N.

AU - Platanias, Leonidas C.

PY - 2013/8/16

Y1 - 2013/8/16

N2 - Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

AB - Background: The mechanisms by which IFNs generate antineoplastic responses remain to be defined. Results: Type I IFN treatment results in activation of the Mnk/eIF4E pathway in Jak2V617F-transformed cells, and this activation is required for the antineoplastic effect. Conclusion: Mnk kinases are essential for the antineoplastic effects of IFN. Significance: This study provides evidence for a key mechanism mediating the effects of IFNs in malignant MPN precursors.

UR - https://www.scopus.com/pages/publications/84882425971

U2 - 10.1074/jbc.M113.476192

DO - 10.1074/jbc.M113.476192

M3 - Article

C2 - 23814052

AN - SCOPUS:84882425971

SN - 0021-9258

VL - 288

SP - 23814

EP - 23822

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 33

ER -

Essential role for the Mnk pathway in the inhibitory effects of type i interferons on myeloproliferative neoplasm (MPN) precursors

Abstract

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