Esophageal cancer T-staging on MRI: A preliminary study using cine and static MR sequences

Laura Haefliger, Mario Jreige, Céline Du Pasquier, Jean Baptiste Ledoux, Dorothea Wagner, Styliani Mantziari, Markus Shäfer, Naïk Vietti Violi, Clarisse Dromain

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Objectives: To evaluate the added value of cine MR in addition to static MRI for T-Staging assessment of esophageal cancer (EC). Materials and methods: This prospective monocentric study included 54 patients (mean age 66.3 ± 9.4 years, 46 men) with histologically proven EC. They underwent MRI on a 3 T-scanner in addition to the standard workup. Acquisitions included static and cine sequences (steady-state-free-precession and real-time True-FISP during water ingestion). Three radiologists independently assessed T-staging and diagnosis confidence by reviewing (1) static sequences (S-MRI) and (2) adding cine sequences (SC-MRI). Inter-reader agreement was performed. MRI T-staging was correlated to reference standard T-staging (histopathology or consensus on endoscopic ultrasonography and imaging findings) and to clinical outcome by log-rank test. Results: Both S-MRI and SC-MRI T-staging showed a significant correlation with reference T-staging (rs = 0.667, P < 0.001). SC-MRI showed a slightly better performance in distinguishing T1-T3 from T4 with a sensitivity, specificity and AUC of 76.5% (95% CI: 50.1–93.2), 83.8% (68–93.8) and 0.801 (0.681–0.921) vs 70.6% (44–89.7), 83% (68–93.8) and 0.772 (0.645–0.899) for S-MRI. Compared to S-MRI, SC-MRI increased inter-reader agreement for T4a and T4b (κ = 0.403 and 0.498) and T-staging confidence. Conclusion: MRI is accurate for T-staging of EC. The addition of cine sequences allows better differentiation between T1-T3 and T4 tumors with increased diagnostic confidence and inter-reader agreement.

Original languageEnglish
Article number111001
JournalEuropean Journal of Radiology
Volume166
DOIs
StatePublished - Sep 2023
Externally publishedYes

Keywords

  • Cine MRI
  • Esophageal neoplasm
  • Tumor staging

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