Erythroid-specific transcription

Over the past year, the range of research related to erythroid cell-specific transcription has expanded beyond isolation of its transcriptional players to studies that address more complex yet still fundamental questions: first, whether these factors form part of a larger protein-protein structure; second, how factor interactions with DNA affect the surrounding chromatin configuration; third, how this affects the mechanism of gene switching within the β-like globin cluster; and finally, how these regulators are themselves transcriptionally controlled.