Erythroid development in the mammalian embryo

Margaret H. Baron; Andrei Vacaru; Johnathan Nieves

doi:10.1016/j.bcmd.2013.07.006

Erythroid development in the mammalian embryo

Margaret H. Baron
, Andrei Vacaru
, Johnathan Nieves

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.

Original language	English
Pages (from-to)	213-219
Number of pages	7
Journal	Blood Cells, Molecules, and Diseases
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/j.bcmd.2013.07.006
State	Published - Dec 2013

Keywords

Erythroid differentiation
Fetal liver
Mammalian embryo
Primitive erythropoiesis
Transgenic mice
Yolk sac

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10.1016/j.bcmd.2013.07.006

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title = "Erythroid development in the mammalian embryo",

abstract = "Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.",

keywords = "Erythroid differentiation, Fetal liver, Mammalian embryo, Primitive erythropoiesis, Transgenic mice, Yolk sac",

author = "Baron, \{Margaret H.\} and Andrei Vacaru and Johnathan Nieves",

note = "Funding Information: Work in our lab was supported in part by grants to M.H.B. from the National Institutes of Health ( RO1 HL62248 , DK52191 , and EB02209 ), the Roche Foundation for Anemia Research (grant 9699367999, cycle X ) and the New York State Department of Health (NYSTEM grant N08G-024 ).",

year = "2013",

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doi = "10.1016/j.bcmd.2013.07.006",

language = "English",

volume = "51",

pages = "213--219",

journal = "Blood Cells, Molecules, and Diseases",

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T1 - Erythroid development in the mammalian embryo

AU - Baron, Margaret H.

AU - Vacaru, Andrei

AU - Nieves, Johnathan

N1 - Funding Information: Work in our lab was supported in part by grants to M.H.B. from the National Institutes of Health ( RO1 HL62248 , DK52191 , and EB02209 ), the Roche Foundation for Anemia Research (grant 9699367999, cycle X ) and the New York State Department of Health (NYSTEM grant N08G-024 ).

PY - 2013/12

Y1 - 2013/12

N2 - Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.

AB - Erythropoiesis is the process by which progenitors for red blood cells are produced and terminally differentiate. In all vertebrates, two morphologically distinct erythroid lineages (primitive, embryonic, and definitive, fetal/adult) form successively within the yolk sac, fetal liver, and marrow and are essential for normal development. Red blood cells have evolved highly specialized functions in oxygen transport, defense against oxidation, and vascular remodeling. Here we review key features of the ontogeny of red blood cell development in mammals, highlight similarities and differences revealed by genetic and gene expression profiling studies, and discuss methods for identifying erythroid cells at different stages of development and differentiation.

KW - Erythroid differentiation

KW - Fetal liver

KW - Mammalian embryo

KW - Primitive erythropoiesis

KW - Transgenic mice

KW - Yolk sac

UR - https://www.scopus.com/pages/publications/84886250047

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DO - 10.1016/j.bcmd.2013.07.006

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VL - 51

SP - 213

EP - 219

JO - Blood Cells, Molecules, and Diseases

JF - Blood Cells, Molecules, and Diseases

IS - 4

ER -

Erythroid development in the mammalian embryo

Abstract

Keywords

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