Erratum: Portability of 245 polygenic scores when derived from the UK Biobank and applied to 9 ancestry groups from the same cohort (The American Journal of Human Genetics (2022) 109(1) (12–23), (S0002929721004201), (10.1016/j.ajhg.2021.11.008))

Florian Privé, Hugues Aschard, Shai Carmi, Lasse Folkersen, Clive Hoggart, Paul F. O'Reilly, Bjarni J. Vilhjálmsson

Research output: Contribution to journalComment/debate

13 Scopus citations

Abstract

(The American Journal of Human Genetics 109, 12–23; January 6, 2022) An unfortunate corruption of two equations on page 14 appeared in the version of this paper published on January 6. It has been corrected here and online. The publisher apologizes for this error. New formula used in LDpred2 We also slightly modify the formula used in Privé et al.;32 we have previously used [Formula presented] where [Formula presented] is the marginal effect of variant j, and where [Formula presented] and [Formula presented] are the vectors of phenotypes and genotypes for variant j residualized from K covariates, e.g., centering them. The first approximation expects [Formula presented] to be small, while the second approximation assumes the effects from covariates are small. However, we have found here that some variants can have very large effects, e.g., one variant explains about 30% of the variance in bilirubin log-concentration. Then, instead we compute [Formula presented] which now gives [Formula presented] finally giving (note the added term [Formula presented]) [Formula presented] Figure S23 shows that the updated formula Equation 1 is better; we now use it in the code of LDpred2, and also recommend using it for the QC procedure proposed in Privé et al.32

Original languageEnglish
Pages (from-to)373
Number of pages1
JournalAmerican Journal of Human Genetics
Volume109
Issue number2
DOIs
StatePublished - 3 Feb 2022

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