Erratum: Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms (Cell (2019) 179(3) (750–771.e22), (S0092867419310724), (10.1016/j.cell.2019.09.021))

Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

(Cell 179, 750–771.e1–e22; October 17, 2019) A reader has called our attention to an error in the Methods in our description of the cis-window for the eQTL analysis, related to the data in Table S1. It originally stated, “a defined cis window of 1 megabase up- and down-stream of the transcription start site,” but should state “a defined cis window of 1 megabase up- and down-stream of the gene start site regardless of strand.” Based on this, we have corrected Table S1, to provide the actual distance to the TSS for the top SNP per eGene. Additionally, we reanalyzed the data by considering strand information to assign the TSS (gene start for + strand genes and gene end for – strand genes) in the input to FastQTL. There is a 99% overlap (6508/6546 remain significant), resulting in no substantial differences in eGenes with both methods. The major difference is that in the new analysis, we find 52 additional new eGenes and 38, which no longer reach our stringent threshold for significance. However, the conclusions of the paper and interpretation of the data remain unchanged. We apologize for any confusion this error has caused.

Original languageEnglish
Pages (from-to)745
Number of pages1
JournalCell
Volume181
Issue number3
DOIs
StatePublished - 30 Apr 2020
Externally publishedYes

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