Erratum: DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas (Cell (2016) 167(5) (1264–1280.e18), (S0092867416313393) (10.1016/j.cell.2016.09.054))

  • Laura Herrtwich
  • , Indrajit Nanda
  • , Konstantinos Evangelou
  • , Teodora Nikolova
  • , Veronika Horn
  • , Sagar
  • , Daniel Erny
  • , Jonathan Stefanowski
  • , Leif Rogell
  • , Claudius Klein
  • , Kourosh Gharun
  • , Marie Follo
  • , Maximilian Seidl
  • , Bernhard Kremer
  • , Nikolas Münke
  • , Julia Senges
  • , Manfred Fliegauf
  • , Tom Aschman
  • , Dietmar Pfeifer
  • , Sandrine Sarrazin
  • Michael H. Sieweke, Dirk Wagner, Christine Dierks, Thomas Haaf, Thomas Ness, Mario M. Zaiss, Reinhard E. Voll, Sachin D. Deshmukh, Marco Prinz, Torsten Goldmann, Christoph Hölscher, Anja E. Hauser, Andres J. Lopez-Contreras, Dominic Grün, Vassilis Gorgoulis, Andreas Diefenbach, Philipp Henneke, Antigoni Triantafyllopoulou

Research output: Contribution to journalComment/debate

10 Scopus citations

Abstract

(Cell 167, 1264–1280.e1–e18; November 17, 2016) In our paper, we reported that polyploid macrophages form by mitotic defects and that their formation requires the DNA damage response. It has come to our attention that during the preparation of Figure 2D, we inadvertently duplicated column 1 (depicting the nuclear area of wild-type untreated macrophage precursors) as column 5 (depicting the nuclear area of Myd88−/− macrophage precursors treated with FSL-1). Upon discovering this error, we returned to the raw data and found that the correct files for each experimental condition had been generated and stored on the computer but that a manual error had occurred upon import into the Spotfire program for data visualization. In Spotfire, each column of the graph is plotted from an individual data file representing the results of the imaging analysis of each experimental condition, and we had inadvertently used one of the data files twice. We have generated an accurate version of Figure 2D from the original data files, which is shown below. This error in no way affects the results of the paper or the interpretation of the data and we have carefully evaluated all the Spotfire analyses in the manuscript to ensure no other manual errors occurred. We apologize for any confusion or inconvenience this error may have caused.

Original languageEnglish
Pages (from-to)1325-1326
Number of pages2
JournalCell
Volume174
Issue number5
DOIs
StatePublished - 23 Aug 2018

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