TY - JOUR
T1 - Erratum
T2 - Alzheimer's-causing mutations shift Aβ length by destabilizing γ-secretase-Aβn interactions (Cell (2017) 170(3) (443–456.e14), (S0092867417308115), (10.1016/j.cell.2017.07.004))
AU - Szaruga, Maria
AU - Munteanu, Bogdan
AU - Lismont, Sam
AU - Veugelen, Sarah
AU - Horré, Katrien
AU - Mercken, Marc
AU - Saido, Takaomi C.
AU - Ryan, Natalie S.
AU - De Vos, Tatjana
AU - Savvides, Savvas N.
AU - Gallardo, Rodrigo
AU - Schymkowitz, Joost
AU - Rousseau, Frederic
AU - Fox, Nick C.
AU - Hopf, Carsten
AU - De Strooper, Bart
AU - Chávez-Gutiérrez, Lucía
N1 - Publisher Copyright:
© 2021
PY - 2021/4/15
Y1 - 2021/4/15
N2 - (Cell 170, 443–456.e1–e14; July 27, 2017) Our paper reported that Alzheimer's disease-linked mutations in Presenilin and the amyloid precursor protein (APP) destabilize interactions between gamma-secretase and APP leading to the production of longer amyloid beta peptides. We have identified two errors in Figure 3C of the manuscript. During preparation of the final figures, we mislabeled the temperature values for the PSEN1 mutants. They should appear as 37, 41.3, 45.7, 51, 55.1, 58.1, 60, 65 °C. Instead, the figure displays 37, 41.3, 45.7, 51, 55.1, 58.1, 60, 62.5, 65 °C. Additionally, the image for the R278I mutant was truncated omitting part of the final lane. This image has been replaced with the full size blot. These changes appear in the corrected figure below. These errors do not affect the results presented or the interpretation of the reported data. The authors apologize to the readers for any confusion these errors may have caused.
AB - (Cell 170, 443–456.e1–e14; July 27, 2017) Our paper reported that Alzheimer's disease-linked mutations in Presenilin and the amyloid precursor protein (APP) destabilize interactions between gamma-secretase and APP leading to the production of longer amyloid beta peptides. We have identified two errors in Figure 3C of the manuscript. During preparation of the final figures, we mislabeled the temperature values for the PSEN1 mutants. They should appear as 37, 41.3, 45.7, 51, 55.1, 58.1, 60, 65 °C. Instead, the figure displays 37, 41.3, 45.7, 51, 55.1, 58.1, 60, 62.5, 65 °C. Additionally, the image for the R278I mutant was truncated omitting part of the final lane. This image has been replaced with the full size blot. These changes appear in the corrected figure below. These errors do not affect the results presented or the interpretation of the reported data. The authors apologize to the readers for any confusion these errors may have caused.
UR - http://www.scopus.com/inward/record.url?scp=85104111824&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2021.03.058
DO - 10.1016/j.cell.2021.03.058
M3 - Comment/debate
C2 - 33861967
AN - SCOPUS:85104111824
SN - 0092-8674
VL - 184
SP - 2257
EP - 2258
JO - Cell
JF - Cell
IS - 8
ER -