Abstract
For intensive treatment, insulin action should be of rapid onset and short duration and effective in reducing postprandial hyperglycemia. In an open, randomised crossover study a total of 14 type-I- and type-II-diabetic patients were treated intensively with Lispro-insulin versus human regular insulin. The postprandial serum insulin levels rose faster and higher following Lispro- versus regular insulin. The rise in postprandial blood glucose was significantly lower following Lispro-insulin; HbA(1c), however, did not improve. Hypoglycemic reaction did not increase. In conclusion, patients perceived an improvement in their postprandial hyperglycemia and their well being. Lispro-insulin seems to be a right step in direction of a more physiological insulin treatment.
| Translated title of the contribution | Experience with Lispro-insulin in the intensified therapy of IDDM and NIDDM patients |
|---|---|
| Original language | German |
| Pages (from-to) | 273-276 |
| Number of pages | 4 |
| Journal | Diabetes und Stoffwechsel |
| Volume | 5 |
| Issue number | 6 |
| State | Published - 1996 |
| Externally published | Yes |
Keywords
- Lispro-insulin
- glucose regulation
- intensified insulin treatment
- pharmacokinetics