Erasing fear memories with extinction training

Gregory J. Quirk, Denis Paré, Rick Richardson, Cyril Herry, Marie H. Monfils, Daniela Schiller, Aleksandra Vicentic

Research output: Contribution to journalArticlepeer-review

173 Scopus citations

Abstract

Decades of behavioral studies have confirmed that extinction does not erase classically conditioned fear memories. For this reason, research efforts have focused on the mechanisms underlying the development of extinction-induced inhibition within fear circuits. However, recent studies in rodents have uncovered mechanisms that stabilize and destabilize fear memories, opening the possibility that extinction might be used to erase fear memories. This symposium focuses on several of these new developments, which involve the timing of extinction training. Extinction-induced erasure of fear occurs in very young rats, but is lost with the development of perineuronal nets in the amygdala that render fear memories impervious to extinction. Moreover, extinction administered during the reconsolidation phase, when fear memory is destabilized, updates the fear association as safe, thereby preventing the return of fear, in both rats and humans. The use of modified extinction protocols to eliminate fear memories complements existing pharmacological strategies for strengthening extinction.

Original languageEnglish
Pages (from-to)14993-14997
Number of pages5
JournalJournal of Neuroscience
Volume30
Issue number45
DOIs
StatePublished - 10 Nov 2010
Externally publishedYes

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