TY - JOUR
T1 - Epstein-Barr Virus–Positive Extranodal Marginal Zone Lymphoma of Bronchial-Associated Lymphoid Tissue in the Posttransplant Setting
T2 - An Immunodeficiency-Related (Posttransplant) Lymphoproliferative Disorder?
AU - Cassidy, Daniel P.
AU - Vega, Francisco
AU - Chapman, Jennifer R.
N1 - Publisher Copyright:
© American Society for Clinical Pathology, 2017. All rights reserved.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Objectives: Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are excluded from the category of PTLD in the current World Health Organization classification. Methods: We report a case of Epstein-Barr virus (EBV)–positive bronchial-associated lymphoid tissue (BALT) lymphoma involving the lungs of a transplant patient. Results: Aside from history of cardiac transplant, young patient age, and EBV positivity, the histopathologic findings were indistinguishable from usual BALT lymphoma. Conclusions: We review the literature of ENMZL occurring in immunocompromised patients and present this case for consideration that this specific entity is a PTLD. We believe that additional studies might lend strength to the hypothesis that this particular group of EBV-positive, posttransplant ENMZLs merits classification and management as PTLDs.
AB - Objectives: Posttransplant lymphoproliferative disorders (PTLDs) are a heterogeneous group of hematolymphoid proliferations arising in the context of chronic immunosuppression. The common and indolent B-cell lymphomas, including extranodal marginal zone lymphomas (ENMZLs) of mucosa-associated lymphoid tissue (MALT), are excluded from the category of PTLD in the current World Health Organization classification. Methods: We report a case of Epstein-Barr virus (EBV)–positive bronchial-associated lymphoid tissue (BALT) lymphoma involving the lungs of a transplant patient. Results: Aside from history of cardiac transplant, young patient age, and EBV positivity, the histopathologic findings were indistinguishable from usual BALT lymphoma. Conclusions: We review the literature of ENMZL occurring in immunocompromised patients and present this case for consideration that this specific entity is a PTLD. We believe that additional studies might lend strength to the hypothesis that this particular group of EBV-positive, posttransplant ENMZLs merits classification and management as PTLDs.
KW - Bronchial-associated lymphoid tissue
KW - Epstein-Barr virus
KW - Extranodal marginal zone lymphoma
KW - Posttransplant lymphoproliferative disorder
UR - http://www.scopus.com/inward/record.url?scp=85042211105&partnerID=8YFLogxK
U2 - 10.1093/AJCP/AQX134
DO - 10.1093/AJCP/AQX134
M3 - Article
C2 - 29228090
AN - SCOPUS:85042211105
SN - 0002-9173
VL - 149
SP - 42
EP - 49
JO - American Journal of Clinical Pathology
JF - American Journal of Clinical Pathology
IS - 1
ER -