Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue

Adora Tricia Santos; Jiankun Tong; Amir Steinberg; Larry Shemen

doi:10.1136/bcr-2020-235100

Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue

Adora Tricia Santos
, Jiankun Tong
, Amir Steinberg
, Larry Shemen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Infection with Epstein-Barr virus (EBV) has been linked to approximately 10%-15% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. NK/T cell lymphoma is a unique type of non-Hodgkin's lymphoma that is almost always associated with EBV. The disease predominantly localises in the upper aerodigestive tract, most commonly in the nose.

Original language	English
Article number	e235100
Journal	BMJ Case Reports
Volume	14
Issue number	11
DOIs	https://doi.org/10.1136/bcr-2020-235100
State	Published - 11 Nov 2021

Keywords

head and neck cancer
head and neck surgery

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10.1136/bcr-2020-235100

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title = "Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue",

abstract = "Infection with Epstein-Barr virus (EBV) has been linked to approximately 10\%-15\% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. NK/T cell lymphoma is a unique type of non-Hodgkin's lymphoma that is almost always associated with EBV. The disease predominantly localises in the upper aerodigestive tract, most commonly in the nose.",

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T1 - Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue

AU - Santos, Adora Tricia

AU - Tong, Jiankun

AU - Steinberg, Amir

AU - Shemen, Larry

N1 - Publisher Copyright: ©

PY - 2021/11/11

Y1 - 2021/11/11

N2 - Infection with Epstein-Barr virus (EBV) has been linked to approximately 10%-15% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. NK/T cell lymphoma is a unique type of non-Hodgkin's lymphoma that is almost always associated with EBV. The disease predominantly localises in the upper aerodigestive tract, most commonly in the nose.

AB - Infection with Epstein-Barr virus (EBV) has been linked to approximately 10%-15% of lymphomas diagnosed in the USA, including a small percentage of Natural Killer (NK)/T cell lymphomas, which are clinically aggressive, respond poorly to chemotherapy and have a shorter survival. Here, we present a case of a patient found to have EBV-induced NK/T cell lymphoma from a chronic EBV infection. While the EBV most commonly infects B cells, it can infect NK/T cells, and it is important for the clinician to be aware of the potential transformation to lymphoma as it is clinically aggressive, warranting early recognition and treatment. NK/T cell lymphoma is a unique type of non-Hodgkin's lymphoma that is almost always associated with EBV. The disease predominantly localises in the upper aerodigestive tract, most commonly in the nose.

KW - head and neck cancer

KW - head and neck surgery

UR - https://www.scopus.com/pages/publications/85119595268

U2 - 10.1136/bcr-2020-235100

DO - 10.1136/bcr-2020-235100

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AN - SCOPUS:85119595268

SN - 1757-790X

VL - 14

JO - BMJ Case Reports

JF - BMJ Case Reports

IS - 11

M1 - e235100

ER -

Epstein-Barr virus-induced natural killer/T cell lymphoma arising in tonsil and cervical node tissue

Abstract

Keywords

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