Abstract
Antibodies to Epstein Barr virus associated cell membrane antigens persisted or slowly decreased during prolonged uncomplicated survival of patients with Burkitt's lymphoma in remission. Serum was sampled from 4 patients within 6 mth before recurrence occurring after the first yr and preceded by remission during more than 6 mth. Rapid and significant decreases of the antibodies before clinical recognition of the recurrences were found in 3 patients. The fourth patient had slowly increasing titers before relapse. Immune stimulant treatment during remission, with Bacille Calmette Guerin vaccine (BCG) or BCG + Bordetella pertussis, temporarily increased the antibody levels. Possible mechanisms for the observed titer changes before recurrence are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 1422-1426 |
| Number of pages | 5 |
| Journal | Proceedings of the National Academy of Sciences of the United States of America |
| Volume | 71 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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