Epoxide hydrolase genotype and orolaryngeal cancer risk: Interaction with GSTM1 genotype

Jong Y. Park, Stimson P. Schantz, Philip Lazarus

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


The human microsomal epoxide hydrolase (EH) gene contains polymorphic alleles which are associated with altered EH activity and may be linked to increased risk for tobacco-related cancers. The objective was to examine the role of EH polymorphisms in orolaryngeal cancer risk. The prevalence of the EH codons 113 and 139 polymorphisms were examined in 81 African American and 142 Caucasian incident orolaryngeal cancer patients and 335 controls frequency-matched on age, sex, and race. In Caucasians, a significant risk increase was observed for subjects with the EH113Tyr variant (OR=2.1, 95% CI=1.1-4.0) and predicted high-activity EH genotypes in heavy-smokers (≥35 pack-years; OR=3.4, 95% CI=1.2-9.6). A significant association between predicted high EH activity genotypes and orolaryngeal cancer risk was observed in Caucasian subjects with the GSTM1 null (OR=3.5, 95% CI=1.3-9.3) but not GSTM [+] (OR=0.9, 95%CI=0.4-2.1) genotype. These results suggest that EH polymorphisms play an important role in risk for orolaryngeal cancer in Caucasians.

Original languageEnglish
Pages (from-to)483-490
Number of pages8
JournalOral Oncology
Issue number5
StatePublished - Jul 2003
Externally publishedYes


  • Cancer susceptibility
  • Epoxide hydrolase
  • Genetic polymorphism
  • Glutathione S-transferase
  • Orolaryngeal cancer


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