TY - JOUR
T1 - Epoxide-diol pathway of δ1 -THC in the rat in vitro
AU - Ben-Zvi, Z.
N1 - Funding Information:
We thank Professor R. Mechoulam, The Hebrew University, Jerusalem, Israel, for encouragement in carrying out this work; Dr J. R. Bend, NIEHS, North Carolina, USA, for labelled styrene oxide, and Mrs P. Ovadia, Chemistry Department, Ben-Gurion University, Beer-Sheva, Israel, for mass spectra. This work was supported by grants from The Israel National Academy of Sciences and The Israeli Authority for Research and Development.
PY - 1980
Y1 - 1980
N2 - 1. 1α2αEpoxyhexahydrocannabinol was identified as a metabolite of Δ1-tetrahydrocannabinol. 2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1α2dihydroxy-hexahydrocannabinol and 12αdihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1α2αepoxyhexahydrocannabinol with rat hepatic microsomes in vitro. 3. The 1α2αepoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide. 4. The synthesis of metabolites of 1α2αepoxyhexahydrocannabinol is described.
AB - 1. 1α2αEpoxyhexahydrocannabinol was identified as a metabolite of Δ1-tetrahydrocannabinol. 2. The two trans-1,2-dihydroxyhexahydrocannabinol isomers, 1α2dihydroxy-hexahydrocannabinol and 12αdihydroxyhexahydrocannabinol (as their acetates) were tentatively identified as metabolites from incubation of 1α2αepoxyhexahydrocannabinol with rat hepatic microsomes in vitro. 3. The 1α2αepoxyhexahydrocannabinol acetate was found to be a good substrate for epoxide hydratase as compared to styrene oxide. 4. The synthesis of metabolites of 1α2αepoxyhexahydrocannabinol is described.
UR - http://www.scopus.com/inward/record.url?scp=0019166821&partnerID=8YFLogxK
U2 - 10.3109/00498258009033810
DO - 10.3109/00498258009033810
M3 - Article
C2 - 6258334
AN - SCOPUS:0019166821
SN - 0049-8254
VL - 10
SP - 805
EP - 809
JO - Xenobiotica
JF - Xenobiotica
IS - 11
ER -