Epithelia: Lymphocyte interactions in the gut

Stephanie Dahan, Franziska Roth-Walter, Paul Arnaboldi, Shradha Agarwal, Lloyd Mayer

Research output: Contribution to journalReview articlepeer-review

104 Scopus citations


The mucosal immune system is governed by a unique set of rules and regulations. The local microenvironment dictates the necessity for these differences. The intestinal epithelial cell (IEC) sits at the interface between an antigen-rich lumen and a lymphocyte-rich lamina propria (LP). The cross talk that occurs between these compartments serves to maintain intestinal homeostasis. IECs have the capacity to talk to LP lymphocytes, activating populations of unique regulatory T cells. These cells have the capacity to talk back to the epithelium, influencing epithelial cell growth and differentiation. This review looks at this cross talk and places it in the context of mucosal immunoregulation.

Original languageEnglish
Pages (from-to)243-253
Number of pages11
JournalImmunological Reviews
Issue number1
StatePublished - Feb 2007


  • Epithelial cells
  • Lamina propria lymphocytes
  • Mucosal immunity


Dive into the research topics of 'Epithelia: Lymphocyte interactions in the gut'. Together they form a unique fingerprint.

Cite this