Epiphyseal involvement in osteosarcoma

Karen I. Norton, George Hermann, Ibrahim F. Abdelwahab, Michael J. Klein, Linda F. Granowetter, Jack G. Rabinowitz

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Plain radiography and magnetic resonance (MR) imaging were used to assess the extent of transphyseal involvement in 15 consecutive patients with long bone osteosarcoma and nonfused epiphyses. The findings were correlated with those from surgical and microscopic pathologic examinations. There were no cases of false-positive findings with either MR imaging or plain radiography. Conventional radiography accurately helped predict transphyseal spread in only nine of 15 cases (60%). Spread to the epiphysis was present in 12 of the 15 cases (80%) and was accurately predicted with MR imaging in all 12 cases. This finding contradicts the common misconception that the physis acts as a "barrier" to tumor spread.

Original languageEnglish
Pages (from-to)813-816
Number of pages4
Issue number3
StatePublished - Sep 1991
Externally publishedYes


  • Bone neoplasms, 40.32
  • Bones, MR studies, 40.1214
  • Children, skeletal system
  • Osteosarcoma, 40.3221


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