TY - JOUR
T1 - Epigenome-Wide Association Analysis Identified Nine Skin DNA Methylation Loci for Psoriasis
AU - Zhou, Fusheng
AU - Wang, Wenjun
AU - Shen, Changbing
AU - Li, Hui
AU - Zuo, Xianbo
AU - Zheng, Xiaodong
AU - Yue, Min
AU - Zhang, Cuicui
AU - Yu, Liang
AU - Chen, Mengyun
AU - Zhu, Caihong
AU - Yin, Xianyong
AU - Tang, Mingjun
AU - Li, Yongjiang
AU - Chen, Gang
AU - Wang, Zaixing
AU - Liu, Shengxiu
AU - Zhou, Yi
AU - Zhang, Fengyu
AU - Zhang, Weijia
AU - Li, Caihua
AU - Yang, Sen
AU - Sun, Liangdan
AU - Zhang, Xuejun
N1 - Funding Information:
We are grateful to all of the subjects for their participation in the study. The project was mainly supported by the National Science Fund for Excellent Youth ( 81222022 ), China, the Program of Outstanding Talents of the Organization Department of the CPC Central Committee, China , the general program of National Science Foundation ( 81573035 ), the Key Program of the National Natural Science Foundation of China ( 81130031 ), the Natural Science Fund of Anhui province ( 1508085JGD05 ), the Local Universities Characteristics and Advantages of Discipline Development Program of the Ministry of Finance of China , the Pre-National Basic Research Program of China (973 Plan; 2012CB722404 ), and the Program of Outstanding Talents of Anhui Medical University .
Publisher Copyright:
© 2015 The Authors
PY - 2016
Y1 - 2016
N2 - Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and environmental factors. DNA methylation has been linked to psoriasis, but the manner in which this process contributes to the disease is not fully understood. In this study, we carried out a three-stage epigenome-wide association study to identify disease-associated differentially methylated sites using a combination of 262 skin and 48 peripheral blood mononuclear cell samples. We not only revealed genome-wide methylation patterns for psoriasis but also identified strong associations between the skin-specific DNA methylation of nine disease-associated differentially methylated sites and psoriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10). Further analysis revealed that these nine disease-associated differentially methylated sites were not significantly affected by genetic variations, supporting their remarkable contributions to disease status. The expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 was negatively correlated with DNA methylation. These findings will help us to better understand the molecular mechanism of psoriasis.
AB - Psoriasis is a chronic hyperproliferative and inflammatory skin disease caused by the interplay of genetic and environmental factors. DNA methylation has been linked to psoriasis, but the manner in which this process contributes to the disease is not fully understood. In this study, we carried out a three-stage epigenome-wide association study to identify disease-associated differentially methylated sites using a combination of 262 skin and 48 peripheral blood mononuclear cell samples. We not only revealed genome-wide methylation patterns for psoriasis but also identified strong associations between the skin-specific DNA methylation of nine disease-associated differentially methylated sites and psoriasis (Wilcoxon ranked PBonferroni < 0.01; methylation level difference > 0.10). Further analysis revealed that these nine disease-associated differentially methylated sites were not significantly affected by genetic variations, supporting their remarkable contributions to disease status. The expression of CYP2S1, ECE1, EIF2C2, MAN1C1, and DLGAP4 was negatively correlated with DNA methylation. These findings will help us to better understand the molecular mechanism of psoriasis.
UR - http://www.scopus.com/inward/record.url?scp=84978151517&partnerID=8YFLogxK
U2 - 10.1016/j.jid.2015.12.029
DO - 10.1016/j.jid.2015.12.029
M3 - Article
C2 - 26743604
AN - SCOPUS:84978151517
SN - 0022-202X
VL - 136
SP - 779
EP - 787
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 4
ER -