TY - JOUR
T1 - Epigenetics
T2 - Tools and technologies
AU - Janzen, William P.
AU - Wigle, Tim J.
AU - Jin, Jian
AU - Frye, Stephen V.
PY - 2010
Y1 - 2010
N2 - Epigenetics refers to heritable changes that control how the genome is accessed in different cell-types and during development and differentiation. Even though each cell contains essentially the same genetic code, epigenetic mechanisms permit specialization of function between cells. The state of chromatin, the complex of histone proteins, RNA and DNA that efficiently package the genome, is largely regulated by specific modifications to histone proteins and DNA, and the recognition of these marks by other proteins and protein complexes. The enzymes that produce these modifications (the 'writers'), the proteins that recognize them (the 'readers'), and the enzymes that remove them (the 'erasers') are crucial targets for manipulation to further understand the histone code and its role in biology and human disease.
AB - Epigenetics refers to heritable changes that control how the genome is accessed in different cell-types and during development and differentiation. Even though each cell contains essentially the same genetic code, epigenetic mechanisms permit specialization of function between cells. The state of chromatin, the complex of histone proteins, RNA and DNA that efficiently package the genome, is largely regulated by specific modifications to histone proteins and DNA, and the recognition of these marks by other proteins and protein complexes. The enzymes that produce these modifications (the 'writers'), the proteins that recognize them (the 'readers'), and the enzymes that remove them (the 'erasers') are crucial targets for manipulation to further understand the histone code and its role in biology and human disease.
UR - https://www.scopus.com/pages/publications/78649909095
U2 - 10.1016/j.ddtec.2010.07.004
DO - 10.1016/j.ddtec.2010.07.004
M3 - Review article
AN - SCOPUS:78649909095
SN - 1740-6749
VL - 7
SP - e59-e65
JO - Drug Discovery Today: Technologies
JF - Drug Discovery Today: Technologies
IS - 1
ER -