Epigenetics in the nervous system

Yan Jiang; Brett Langley; Farah D. Lubin; William Renthal; Marcelo A. Wood; Dag H. Yasui; Arvind Kumar; Eric J. Nestler; Schahram Akbarian; Andrea C. Beckel-Mitchener

doi:10.1523/JNEUROSCI.3797-08.2008

Epigenetics in the nervous system

Yan Jiang, Brett Langley, Farah D. Lubin, William Renthal, Marcelo A. Wood, Dag H. Yasui, Arvind Kumar, Eric J. Nestler, Schahram Akbarian, Andrea C. Beckel-Mitchener

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.

Original language	English
Pages (from-to)	11753-11759
Number of pages	7
Journal	Journal of Neuroscience
Volume	28
Issue number	46
DOIs	https://doi.org/10.1523/JNEUROSCI.3797-08.2008
State	Published - 12 Nov 2008
Externally published	Yes

Keywords

Chromatin
DNA methylation
Epigenetics
Gene
Histone
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10.1523/JNEUROSCI.3797-08.2008

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AU - Lubin, Farah D.

AU - Renthal, William

AU - Wood, Marcelo A.

AU - Yasui, Dag H.

AU - Kumar, Arvind

AU - Nestler, Eric J.

AU - Akbarian, Schahram

AU - Beckel-Mitchener, Andrea C.

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AB - It is becoming increasingly clear that epigenetic modifications are critical factors in the regulation of gene expression. With regard to the nervous system, epigenetic alterations play a role in a diverse set of processes and have been implicated in a variety of disorders. Gaining a more complete understanding of the essential components and underlying mechanisms involved in epigenetic regulation could lead to novel treatments for a number of neurological and psychiatric conditions.

KW - Chromatin

KW - DNA methylation

KW - Epigenetics

KW - Gene

KW - Histone

KW - Transcription

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JO - Journal of Neuroscience

JF - Journal of Neuroscience

IS - 46

ER -

Epigenetics in the nervous system

Abstract

Keywords

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