Epigenetics, genomic mutations and cognitive function

Abraham Reichenberg, Jonathan Mill, James H. MacCabe

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Introduction. There is growing interest in the role of single genes in cognitive functions. Association studies are the most commonly applied method in this field. This method assumes that the genetic information affecting cognitive processes is static and unchanging. However, there is accumulating evidence that dynamic genomic and epigenetic alterations can modulate complex cognitive processes, and influence susceptibility to disorders associated with impaired cognitive functioning. Methods. We present an overview of genomic and epigenetic mechanisms, and discuss the cognitive and psychiatric consequences of genomic and genetic abnormalities. Results. Genomic and epigenetic changes can affect complex cognitive functions, including learning and memory and are causative in several developmental and psychiatric disorders effecting language, social functioning and IQ. Conclusions. Genomic and epigenetic disorders are experiments of nature that offer unique and valuable insight in to the physiology of general and specific cognitive functions.

Original languageEnglish
Pages (from-to)377-390
Number of pages14
JournalCognitive Neuropsychiatry
Issue number4-5
StatePublished - Sep 2009
Externally publishedYes


  • CNV
  • Cognition
  • Epigenetics
  • Genomics
  • Mutations


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