Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

Douglas Hanniford; Alejandro Ulloa-Morales; Alcida Karz; Maria Gabriela Berzoti-Coelho; Rana S. Moubarak; Beatriz Sánchez-Sendra; Andreas Kloetgen; Veronica Davalos; Jochen Imig; Pamela Wu; Varshini Vasudevaraja; Diana Argibay; Karin Lilja; Tommaso Tabaglio; Carlos Monteagudo; Ernesto Guccione; Aristotelis Tsirigos; Iman Osman; Iannis Aifantis; Eva Hernando

doi:10.1016/j.ccell.2019.12.007

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

Douglas Hanniford, Alejandro Ulloa-Morales, Alcida Karz, Maria Gabriela Berzoti-Coelho, Rana S. Moubarak, Beatriz Sánchez-Sendra, Andreas Kloetgen, Veronica Davalos, Jochen Imig, Pamela Wu, Varshini Vasudevaraja, Diana Argibay, Karin Lilja, Tommaso Tabaglio, Carlos Monteagudo, Ernesto Guccione, Aristotelis Tsirigos, Iman Osman, Iannis Aifantis, Eva Hernando

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223 Scopus citations

Abstract

Investigating the role of circular RNAs (circRNA) in metastasis, Hanniford et al. observe epigenetic silencing of circRNA CDR1as in melanoma progression. Depletion of CDR1as promotes melanoma metastasis via an IGF2BP3-mediated mechanism that is independent of its well-characterized regulation of miR-7.

Original language	English
Pages (from-to)	55-70.e15
Journal	Cancer Cell
Volume	37
Issue number	1
DOIs	https://doi.org/10.1016/j.ccell.2019.12.007
State	Published - 13 Jan 2020

Keywords

CDR1as
EZH2
GPX4
IGF2BP
LINC00632
PRC2
circRNA
melanoma
metastasis
miR-7

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10.1016/j.ccell.2019.12.007

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Hanniford, D., Ulloa-Morales, A., Karz, A., Berzoti-Coelho, M. G., Moubarak, R. S., Sánchez-Sendra, B., Kloetgen, A., Davalos, V., Imig, J., Wu, P., Vasudevaraja, V., Argibay, D., Lilja, K., Tabaglio, T., Monteagudo, C., Guccione, E., Tsirigos, A., Osman, I., Aifantis, I., & Hernando, E. (2020). Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis. Cancer Cell, 37(1), 55-70.e15. https://doi.org/10.1016/j.ccell.2019.12.007

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title = "Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis",

abstract = "Investigating the role of circular RNAs (circRNA) in metastasis, Hanniford et al. observe epigenetic silencing of circRNA CDR1as in melanoma progression. Depletion of CDR1as promotes melanoma metastasis via an IGF2BP3-mediated mechanism that is independent of its well-characterized regulation of miR-7.",

keywords = "CDR1as, EZH2, GPX4, IGF2BP, LINC00632, PRC2, circRNA, melanoma, metastasis, miR-7",

author = "Douglas Hanniford and Alejandro Ulloa-Morales and Alcida Karz and Berzoti-Coelho, {Maria Gabriela} and Moubarak, {Rana S.} and Beatriz S{\'a}nchez-Sendra and Andreas Kloetgen and Veronica Davalos and Jochen Imig and Pamela Wu and Varshini Vasudevaraja and Diana Argibay and Karin Lilja and Tommaso Tabaglio and Carlos Monteagudo and Ernesto Guccione and Aristotelis Tsirigos and Iman Osman and Iannis Aifantis and Eva Hernando",

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year = "2020",

month = jan,

day = "13",

doi = "10.1016/j.ccell.2019.12.007",

language = "English",

volume = "37",

pages = "55--70.e15",

journal = "Cancer Cell",

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Hanniford, D, Ulloa-Morales, A, Karz, A, Berzoti-Coelho, MG, Moubarak, RS, Sánchez-Sendra, B, Kloetgen, A, Davalos, V, Imig, J, Wu, P, Vasudevaraja, V, Argibay, D, Lilja, K, Tabaglio, T, Monteagudo, C, Guccione, E, Tsirigos, A, Osman, I, Aifantis, I & Hernando, E 2020, 'Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis', Cancer Cell, vol. 37, no. 1, pp. 55-70.e15. https://doi.org/10.1016/j.ccell.2019.12.007

TY - JOUR

T1 - Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

AU - Hanniford, Douglas

AU - Ulloa-Morales, Alejandro

AU - Karz, Alcida

AU - Berzoti-Coelho, Maria Gabriela

AU - Moubarak, Rana S.

AU - Sánchez-Sendra, Beatriz

AU - Kloetgen, Andreas

AU - Davalos, Veronica

AU - Imig, Jochen

AU - Wu, Pamela

AU - Vasudevaraja, Varshini

AU - Argibay, Diana

AU - Lilja, Karin

AU - Tabaglio, Tommaso

AU - Monteagudo, Carlos

AU - Guccione, Ernesto

AU - Tsirigos, Aristotelis

AU - Osman, Iman

AU - Aifantis, Iannis

AU - Hernando, Eva

PY - 2020/1/13

Y1 - 2020/1/13

N2 - Investigating the role of circular RNAs (circRNA) in metastasis, Hanniford et al. observe epigenetic silencing of circRNA CDR1as in melanoma progression. Depletion of CDR1as promotes melanoma metastasis via an IGF2BP3-mediated mechanism that is independent of its well-characterized regulation of miR-7.

AB - Investigating the role of circular RNAs (circRNA) in metastasis, Hanniford et al. observe epigenetic silencing of circRNA CDR1as in melanoma progression. Depletion of CDR1as promotes melanoma metastasis via an IGF2BP3-mediated mechanism that is independent of its well-characterized regulation of miR-7.

KW - CDR1as

KW - EZH2

KW - GPX4

KW - IGF2BP

KW - LINC00632

KW - PRC2

KW - circRNA

KW - melanoma

KW - metastasis

KW - miR-7

UR - http://www.scopus.com/inward/record.url?scp=85077567555&partnerID=8YFLogxK

U2 - 10.1016/j.ccell.2019.12.007

DO - 10.1016/j.ccell.2019.12.007

M3 - Article

C2 - 31935372

AN - SCOPUS:85077567555

SN - 1535-6108

VL - 37

SP - 55-70.e15

JO - Cancer Cell

JF - Cancer Cell

IS - 1

ER -

Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis

Abstract

Keywords

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