Epigenetic signaling in schizophrenia

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations

Abstract

Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes. Psychiatric disorders such as schizophrenia and depression are complex and heterogeneous diseases with multiple and independent factors that may contribute to their pathophysiology, making challenging to find a link between specific elements and the underlying mechanisms responsible for the disorder and its treatment. Growing evidences suggest that epigenetic modifications in certain brain regions and neural circuits represent a key mechanism through which environmental factors interact with individual's genetic constitution to affect risk of psychiatric conditions throughout life. This review focuses on recent advances that directly implicate epigenetic modifications in schizophrenia and antipsychotic drug action.

Original languageEnglish
Pages (from-to)2131-2136
Number of pages6
JournalCellular Signalling
Volume27
Issue number10
DOIs
StatePublished - 1 Oct 2015

Keywords

  • Antipsychotics
  • Epigenetics
  • Histone deacetylases (HDACs)
  • Histones
  • Schizophrenia

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