Epigenetic regulatory mutations and epigenetic therapy for multiple myeloma

Daphné Dupéré-Richer, Jonathan D. Licht

Research output: Contribution to journalReview articlepeer-review

35 Scopus citations

Abstract

Purpose of review: Next generation sequencing and large-scale analysis of patient specimens has created a more complete picture of multiple myeloma (MM) revealing that epigenetic deregulation is a prominent factor in MM pathogenesis. Recent findings: Over half of MM patients have mutations in genes encoding epigenetic modifier enzymes. The DNA methylation profile of MM is related to the stage of the disease and certain classes of mutations in epigenetic modifiers are more prevalent upon disease relapse, suggesting a role in disease progression. Many small molecules targeting regulators of epigenetic machinery have been developed and clinical trials are underway for some of these in MM. Summary: Recent findings suggest that epigenetic targeting drugs could be an important strategy to cure MM. Combining these agents along with other strategies to affect the MM cell such as immunomodulatory drugs and proteasome inhibitors may enhance efficacy of combination regimens in MM.

Original languageEnglish
Pages (from-to)336-344
Number of pages9
JournalCurrent Opinion in Hematology
Volume24
Issue number4
DOIs
StatePublished - 1 Jul 2017
Externally publishedYes

Keywords

  • DNA methylation
  • epigenetics
  • histone acetylation
  • myeloma

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