Epigenetic regulation of skin: Focus on the Polycomb complex

Jisheng Zhang, Evan Bardot, Elena Ezhkova

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations

Abstract

Chromatin regulators have recently emerged as key players in the control of tissue development and tumorigenesis. One specific chromatin regulator, the Polycomb complex, has been shown to regulate the identity of embryonic stem cells, but its role in controlling fates of multipotent progenitors in developing tissues is still largely unknown. Recent findings have revealed that this complex plays a critical role in control of skin stem cell renewal and differentiation. Moreover, the expression of Polycomb complex components is often aberrant in skin diseases, including skin cancers. This review will detail recent findings on Polycomb control of skin and highlight critical unknown questions.

Original languageEnglish
Pages (from-to)2161-2172
Number of pages12
JournalCellular and Molecular Life Sciences
Volume69
Issue number13
DOIs
StatePublished - Jul 2012

Keywords

  • Chromatin regulators
  • Skin
  • Skin cancer
  • Stem cells
  • Tissue development

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