TY - JOUR
T1 - Epigenetic regulation of oligodendrocyte identity
AU - Liu, Jia
AU - Casaccia, Patrizia
N1 - Funding Information:
Dr. Casaccia acknowledges funds from the National Institutes of Health–National Institute of Neurological Disorders and Stroke (NIH–NINDS) grants R01-52738, R01-42925 and R01NS042925-07S1. The authors apologize to all the colleagues whose outstanding work could not be cited owing to space limitations.
PY - 2010/4
Y1 - 2010/4
N2 - The interplay of transcription factors and epigenetic modifiers, including histone modifications, DNA methylation and microRNAs during development is essential for the acquisition of specific cell fates. Here, we review the epigenetic " programming" of stem cells into oligodendrocytes, by analyzing three sequential stages of lineage progression. The first transition from pluripotent stem cells to neural precursors is characterized by repression of pluripotency genes and restriction of the lineage potential to the neural fate. The second transition from multipotential precursors to oligodendrocyte progenitors is associated with the progressive loss of plasticity and the repression of neuronal and astrocytic genes. The last step of differentiation of oligodendrocyte progenitors into myelin-forming cells is defined by a model of derepression of myelin genes.
AB - The interplay of transcription factors and epigenetic modifiers, including histone modifications, DNA methylation and microRNAs during development is essential for the acquisition of specific cell fates. Here, we review the epigenetic " programming" of stem cells into oligodendrocytes, by analyzing three sequential stages of lineage progression. The first transition from pluripotent stem cells to neural precursors is characterized by repression of pluripotency genes and restriction of the lineage potential to the neural fate. The second transition from multipotential precursors to oligodendrocyte progenitors is associated with the progressive loss of plasticity and the repression of neuronal and astrocytic genes. The last step of differentiation of oligodendrocyte progenitors into myelin-forming cells is defined by a model of derepression of myelin genes.
UR - http://www.scopus.com/inward/record.url?scp=77950867183&partnerID=8YFLogxK
U2 - 10.1016/j.tins.2010.01.007
DO - 10.1016/j.tins.2010.01.007
M3 - Review article
C2 - 20227775
AN - SCOPUS:77950867183
SN - 0378-5912
VL - 33
SP - 193
EP - 201
JO - Trends in Neurosciences
JF - Trends in Neurosciences
IS - 4
ER -