Epigenetic regulation of axon regeneration and glial activation in injury responses

Shalaka Wahane, Dalia Halawani, Xiang Zhou, Hongyan Zou

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Injury to the nervous system triggers a multicellular response in which epigenetic mechanisms play an important role in regulating cell type-specific transcriptional changes. Here, we summarize recent progress in characterizing neuronal intrinsic and extrinsic chromatin reconfigurations and epigenetic changes triggered by axonal injury that shape neuroplasticity and glial functions. We specifically discuss regeneration-associated transcriptional modules comprised of transcription factors and epigenetic regulators that control axon growth competence. We also review epigenetic regulation of neuroinflammation and astroglial responses that impact neural repair. These advances provide a framework for developing epigenetic strategies to maximize adaptive alterations while minimizing maladaptive stress responses in order to enhance axon regeneration and achieve functional recovery after injury.

Original languageEnglish
Article number640
JournalFrontiers in Genetics
Issue numberJUL
StatePublished - 2019


  • Axon regeneration
  • CNS injury
  • Chromatin accessibility
  • Epigenetic regulation
  • Neural repair
  • Neuroepigenetics
  • Neuroinflammation
  • Spinal cord injury


Dive into the research topics of 'Epigenetic regulation of axon regeneration and glial activation in injury responses'. Together they form a unique fingerprint.

Cite this