Epigenetic Mechanisms of Serotonin Signaling

Terrell Holloway, Javier González-Maeso

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


Histone modifications and DNA methylation represent central dynamic and reversible processes that regulate gene expression and contribute to cellular phenotypes. These epigenetic marks have been shown to play fundamental roles in a diverse set of signaling and behavioral outcomes. Serotonin is a monoamine that regulates numerous physiological responses including those in the central nervous system. The cardinal signal transduction mechanisms via serotonin and its receptors are well established, but fundamental questions regarding complex interactions between the serotonin system and heritable epigenetic modifications that exert control on gene function remain a topic of intense research and debate. This review focuses on recent advances and contributions to our understanding of epigenetic mechanisms of serotonin receptor-dependent signaling, with focus on psychiatric disorders such as schizophrenia and depression.

Original languageEnglish
Pages (from-to)1099-1109
Number of pages11
JournalACS Chemical Neuroscience
Issue number7
StatePublished - 15 Jul 2015


  • G protein-coupled receptors (GPCRs)
  • Schizophrenia
  • antipsychotics
  • epigenetics
  • hallucinogens
  • histone deacetylases (HDACs)
  • lysergic acid diethylamide (LSD)
  • psychosis
  • serotonin 5-HT<inf>2A</inf> receptor


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