Epigenetic mechanisms facilitating oligodendrocyte development, maturation, and aging

Sjef Copray, Jimmy Long Huynh, Falak Sher, Patrizia Casaccia-Bonnefil, Erik Boddeke

Research output: Contribution to journalReview articlepeer-review

58 Scopus citations


The process of oligodendrocyte differentiation is regulated by a dynamic interaction between a genetic and an epigenetic program. Recent studies, addressing nucleosomal histone modifications have considerably increased our knowledge regarding epigenetic regulation of gene expression during oligodendrocyte development and aging. These results have generated new hypotheses regarding the mechanisms underlying the decreased efficiency of endogenous remyelination in response to demyelinating injuries with increasing age. In this review, we present an overview of the epigenetic mechanisms regulating gene expression at specific stages of oligodendrocyte differentiation and maturation as well as the changes that occur with aging.

Original languageEnglish
Pages (from-to)1579-1587
Number of pages9
Issue number15
StatePublished - 15 Nov 2009
Externally publishedYes


  • Histone modification
  • Multiple sclerosis
  • Oligodendrocyte differentiation
  • micro-RNA


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