TY - JOUR
T1 - Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis
AU - Miroshnikova, Yekaterina A.
AU - Cohen, Idan
AU - Ezhkova, Elena
AU - Wickström, Sara A.
N1 - Publisher Copyright:
© 2019 The Authors
PY - 2019/4
Y1 - 2019/4
N2 - The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
AB - The skin epidermis is a constantly renewing stratified epithelium that provides essential protective barrier functions throughout life. Epidermal stratification is governed by a step-wise differentiation program that requires precise spatiotemporal control of gene expression. How epidermal self-renewal and differentiation are regulated remains a fundamental open question. Cell-intrinsic and cell-extrinsic mechanisms that modify chromatin structure and interactions have been identified as key regulators of epidermal differentiation and stratification. Here, we will review the recent advances in our understanding of how chromatin modifiers, tissue-specific transcription factors, and force-induced nuclear remodeling processes function to shape chromatin and to control epidermal tissue development and homeostasis.
UR - http://www.scopus.com/inward/record.url?scp=85065699767&partnerID=8YFLogxK
U2 - 10.1016/j.gde.2019.04.014
DO - 10.1016/j.gde.2019.04.014
M3 - Review article
C2 - 31112907
AN - SCOPUS:85065699767
SN - 0959-437X
VL - 55
SP - 46
EP - 51
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
ER -