TY - JOUR
T1 - Epigenetic control of oligodendrocyte development
T2 - Adding new players to old keepers
AU - Liu, Jia
AU - Moyon, Sarah
AU - Hernandez, Marylens
AU - Casaccia, Patrizia
N1 - Funding Information:
We thank members of the Casaccia laboratory and Dr. Karen Dietz for their insightful feedback on the manuscript. This review is supported by the National Institute of Neurological Disorders and Stroke ( 2R37NS042925-10 , R01NS52738 to P.C.), and by postdoctoral fellowships from the Paralyzed Veterans of America (3061) and National Multiple Sclerosis Society ( FG-1507-04996 ) to S.M. We apologize to our colleagues whose work we did not cite due to limited space.
Publisher Copyright:
© 2016 Elsevier Ltd.
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Emerging and strengthening evidence suggests an important role of myelin in plasticity and axonal survival. However, the mechanisms regulating progression from oligodendrocyte progenitor cells (OPCs) to myelinating oligodendrocytes remain only partially understood. A series of overlapping yet distinct epigenetic events occur as a proliferating OPC exits the cell cycle, initiates differentiation, and becomes a myelin-forming oligodendrocyte that wraps axons. Here we discuss recent advances towards understanding the epigenetic control of oligodendrocyte development that integrates environmental stimuli. We suggest that OPCs are directly responsive to extrinsic signals due to predominantly euchromatic nuclei, while the heterochromatic nuclei render differentiating and myelinating cells less susceptible to signals modulating the epigenome.
AB - Emerging and strengthening evidence suggests an important role of myelin in plasticity and axonal survival. However, the mechanisms regulating progression from oligodendrocyte progenitor cells (OPCs) to myelinating oligodendrocytes remain only partially understood. A series of overlapping yet distinct epigenetic events occur as a proliferating OPC exits the cell cycle, initiates differentiation, and becomes a myelin-forming oligodendrocyte that wraps axons. Here we discuss recent advances towards understanding the epigenetic control of oligodendrocyte development that integrates environmental stimuli. We suggest that OPCs are directly responsive to extrinsic signals due to predominantly euchromatic nuclei, while the heterochromatic nuclei render differentiating and myelinating cells less susceptible to signals modulating the epigenome.
UR - http://www.scopus.com/inward/record.url?scp=84973904888&partnerID=8YFLogxK
U2 - 10.1016/j.conb.2016.06.002
DO - 10.1016/j.conb.2016.06.002
M3 - Review article
C2 - 27308779
AN - SCOPUS:84973904888
SN - 0959-4388
VL - 39
SP - 133
EP - 138
JO - Current Opinion in Neurobiology
JF - Current Opinion in Neurobiology
ER -