Epidemiology research and epigenetics: Translational epidemiology of schizophrenia

Mary Perrin, Karine Kleinhaus, Mark Opler, Julie Messinger, Dolores Malaspina

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Scopus citations

Abstract

Epigenetic processes can explain some of the epidemiological associations between environmental exposure and disease, particularly when the exposure occurs at a critical developmental stage. In this chapter, we present several epigenetic pathways associated with the risk for schizophrenia. We discuss nongenetic factors - such as paternal age, toxin exposure, and psychological stressors - which may influence human development by way of epigenetic mechanisms.

Original languageEnglish
Title of host publicationEpigenetics and Human Reproduction
Pages71-96
Number of pages26
DOIs
StatePublished - 2011
Externally publishedYes

Publication series

NameEpigenetics and Human Health
ISSN (Print)2191-2262
ISSN (Electronic)2191-2270

Keywords

  • Environmental toxins
  • Imprinting
  • Intrauterine stress
  • Paternal age
  • X-chromosome

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